MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 6080-58-6
MCE 国际站:Lithium citrate tetrahydrate
产品活性:Lithium citrate (Litarex) tetrahydrate 是藤黄果的主要活性成分。Lithium citrate tetrahydrate 可竞争性抑制柠檬酸裂解酶 (ATP citrate lyase) ,并具有减肥效果。Lithium citrate tetrahydrate 有效抑制结石形成并抑制 HIF,具有抗氧化,抗炎和抗肿瘤作用。
研究领域:Metabolic Enzyme/Protease | Anti-infection
作用靶点:ATP Citrate Lyase | Bacterial | HIF/HIF Prolyl-Hydroxylase | Endogenous Metabolite
结构分类:酮、醛、酸 | 结构分类
In Vitro: Lithium citrate tetrahydrate shows an HIF inhibitory effect compared with the control group in ARPE19 cells and 661W cells. Lithium citrate tetrahydrate can downregulate Hif1a and the downstream genes in ARPE19 cells and 661W cells. Lithium citrate tetrahydrate suppresses HIF-1α protein expression increased by CoCl2 administration in ARPE19 cells and 661W cells.
In chicken hepatocytes, Lithium citrate tetrahydrate decreases the accumulation of lipid droplets and accelerated energy metabolism. Lithium citrate tetrahydrate protects the cells from ER stress by increasing the antioxidant status and mitochondrial functions.
In Vivo: Lithium citrate (100-200 mg/kg) tetrahydrate treatment could reduce markers of renal impairment (Blood Urea Nitrogen and serum creatinine). There is significantly less calcium oxalate crystal deposition in mice (male C57BL/6J mice) treated with Lithium citrate tetrahydrate. Lithium citrate tetrahydrate attenuates the oxidative stress induced by calcium oxalate crystallization. Lithium citrate tetrahydrate has inhibitory effects on calcium oxalate-induced inflammatory cytokines, such as MCP-1, IL-1 β, and IL-6. In addition, Lithium citrate tetrahydrate alleviates tubular injury and apoptosis caused by calcium oxalate crystals.
The administration of Lithium citrate tetrahydrate can suppress body weight gain and fat accumulation in animals.
相关产品:Natural Product Library Plus | Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Anti-Infection Compound Library | Epigenetics Compound Library | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | Natural Product Library | FDA-Approved Drug Library | Anti-Cancer Compound Library | Human Endogenous Metabolite Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Antibacterial Compound Library | Anti-COVID-19 Compound Library | Endoplasmic Reticulum Stress Compound Library | Medicine Food Homology Compound Library | Orally Active Compound Library | Glutamine Metabolism Compound Library | Traditional Chinese Medicine Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Anti-Breast Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Microbial Metabolite Library | Angiogenesis-Related Compound Library | Transcription Factor-Targeted Library | Lipid Metabolism Compound Library | Glucose Metabolism Compound Library | Anti-Cancer Natural Product Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | FDA-Approved Anticancer Drug Library | Human Metabolite Library | Non-steroidal Anti-Inflammatory Compound Library | Anti-Aging Natural Product Library | Cancer Stem Cells Compound Library | Off-patent Drug Library | D-Valine-d8 | D-α-Hydroxyglutaric acid disodium | Myricetin 3-O-α-L-arabinopyranoside | Nicotinamide N-oxide | (1R,2S,7R)-Sitafloxacin-d4 hydrochloride | Nebacumab | Deoxycholic acid-d5 | Doxorubicin-13C,d3 TFA | Gepotidacin | Amycolatopsin A | Palitantin | Antibiotic A-33853 | Estradiol hemihydrate | Sulbactam-d2 sodium | Adrenaline sulfate | Oleic acid-13C | Dextranase | Antimicrobial agent-5 | NBTIs-IN-4 | H2S Donor 5a | Proanthocyanidins | Anticancer agent 120 | Azlocillin sodium salt | Methylmalonic acid | Antitubercular agent-13 | Glycine, N-(aminoiminomethyl)-N-methyl-13C | Dihydroxyacetone phosphate | Lenampicillin hydrochloride | Sphingomyelin | (-)-Jasmonoyl-L-isoleucine
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-B1295
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。