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Oxypaeoniflorin

CAS No. : 39011-91-1

MCE 国际站：Oxypaeoniflorin

产品活性：Oxypaeoniflorin 是一种抗氧化剂，是从 Paeoniae 中分离得到的单萜糖苷化合物。Oxypaeoniflorin 具有神经保护和抗炎作用。

研究领域：Others

作用靶点：Others

结构分类：萜类  |  其他单萜  |  酚类  |  单酚类

来源：植物  |  芍药科  |  芍药

In Vitro: Oxypaeoniflorin (OPA; 0.1-10 µM; 8 hours) obviously reversed the hypoxia/reoxygenation (H/R)-induced decrease in cell activity and increase in apoptosis of H9c2 cells. Oxypaeoniflorin inhibits apoptosis by activating the Sirt1 (silent information regulator factor 2 related enzyme 1)/Foxo1(forkhead transcription factor FKHR) signaling pathway in myocardial tissues and H9c2 cells.
Oxypaeoniflorin (0-30 μM) attenuates inflammatory effects via regulation of the toll-like receptor (TLR), extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases signaling pathways in LPS-stimulated RAW264.7 cells.

In Vivo: Oxypaeoniflorin (OPA; 10-40 mg/kg; intragastrical administration; every day; for 30 days) treatment significantly reduces disruption of cardiac function and improves the indicators of ejection fraction (EF) and fractional shortening (FS). Oxypaeoniflorin significantly reduces the release of myocardial infarction-related factors, such as the creatine kinase (CK-MB), cardiac troponin I (cTnI) and cardiac troponin T (cTnT).

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