MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 10605-02-4
MCE 国际站:Palmatine chloride
产品活性:Palmatine chloride 是一种具有口服活性的、不可逆的 IDO-1 抑制剂,对 HEK 293-hIDO-1 和 rhIDO-1 的 IC50 分别为 3 μM 和 157 μM。Palmatine chloride 也能非竞争性抑制西尼罗病毒 (WNV) NS2B-NS3 蛋白酶,IC50 为 96 μM。Palmatine chloride 具有抗癌、抗炎、神经保护、抗细菌、抗病毒活性。
研究领域:Metabolic Enzyme/Protease | Anti-infection | Epigenetics | Cell Cycle/DNA Damage | Apoptosis
作用靶点:Indoleamine 2,3-Dioxygenase (IDO) | Virus Protease | Aurora Kinase | Apoptosis | Bacterial | Parasite
结构分类:生物碱 | 异喹啉类生物碱
来源:植物 | 芸香科 | 黄柏
In Vitro: Palmatine (0-100 μM; 42 h) suppresses WNV with an EC50 value of 3.6 μM, and reduce the viral titers of DENV-2 and YFV with EC50 values of 26.4 μM and 7.3 μM, respectively.
Palmatine (0-1128 μM; 24-72 h) inhibits colon cancer cell proliferation.
Palmatine (0-704 μM; 24 h) reduces AURKA protein levels, induces G2/M phase arrest, and induces apoptosis in colon cancer cells via the mitochondrial associated pathway.
In Vivo: Palmatine (50 or 100 mg/kg; p.o.; daily for 7 days) ameliorates DSS (dextran sulfate sodium)-induced colitis and prevents infiltration of inflammatory cells.Palmatine (0-200 mg/kg; i.p.; once) attenuates D-galactosamine/Lipopolysaccharides (HY-D1056)-induced fulminant hepatic failure in mice.Palmatine (0-1 mg/kg; i.p.; 10 days) shows memory-enhancing activity in mice.Palmatine (33.75-135 mg/kg; p.o.; daily for 26 days) can effectively inhibit the growth of HCT-116 xenografts in mice.
相关产品:Covalent Screening Library Plus | Natural Product Library Plus | Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Anti-Infection Compound Library | Apoptosis Compound Library | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | Metabolism/Protease Compound Library | Natural Product Library | FDA-Approved Drug Library | Anti-Cancer Compound Library | Antiviral Compound Library | Autophagy Compound Library | Small Molecule Immuno-Oncology Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Covalent Screening Library | Antibacterial Compound Library | NMPA-Approved Drug Library | Orally Active Compound Library | Traditional Chinese Medicine Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Neuroprotective Compound Library | Alkaloids Library | Anti-Blood Cancer Compound Library | Antiparasitic Compound library | Targeted Diversity Library | Anti-Cancer Natural Product Library | Antiviral Traditional Chinese Medicine Active Compound Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | FDA-Approved Anticancer Drug Library | Heterocyclic Compound Library | Off-patent Drug Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | SY-5609 | Antifungal agent 26 | Myricetin 3-O-α-L-arabinopyranoside | BRD4 Inhibitor-18 | 8α-Tigloyloxyhirsutinolide 13-O-acetate | (1R,2S,7R)-Sitafloxacin-d4 hydrochloride | Quinidine-d3 | Nebacumab | Angulatin G | Acridine Orange base | N-Desethyl amodiaquine-d5 | Gepotidacin | Amycolatopsin A | SRPIN340 | Palitantin | Antibiotic A-33853 | Estradiol hemihydrate | AAPK-25 | Sulbactam-d2 sodium | Dutasteride-13C6 | Oleic acid-13C | Antimicrobial agent-5 | Proguanil-d6 | NBTIs-IN-4 | Proanthocyanidins | Anticancer agent 120 | Azlocillin sodium salt | Abacavir sulfate | Antitubercular agent-13
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-N0110
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。