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Oxyresveratrol

CAS No. : 29700-22-9

MCE 国际站：Oxyresveratrol

产品活性：Oxyresveratrol (trans-Oxyresveratrol) 是一种有效的天然抗氧化剂和自由基清除剂 (对 DPPH 自由基的 IC₅₀ 为 28.9 µM)。Oxyresveratrol 是一种有效的非竞争性酪氨酸酶 (tyrosinase) 抑制剂，对蘑菇酪氨酸酶的 IC₅₀ 值为 1.2 µM。Oxyresveratrol 对 HSV-1，HSV-2 和水痘带状疱疹病毒 (varicella-zoster virus) 有效，并具有神经保护作用。

研究领域：Metabolic Enzyme/Protease  |  Anti-infection  |  Autophagy

作用靶点：Tyrosinase  |  HSV  |  Autophagy

结构分类：酚类  |  多酚类  |  二苯乙烯类

来源：植物  |  其他科

In Vitro: Cultures of the murine microglial cell line N9 and primary mixed glial cultures were used to test the drug effects of NO production upon expression of the inducible isoform of nitric oxide synthase (iNOS). Oxyresveratrol considerably diminished NO (nitrite) levels (IC₅₀ of 45.31 µM) in murine microglial cells.
Oxyresveratrol can inhibit DOPA oxidase activity, cyclooxygenase, and rat liver mitochondrial ATPase activity.
Oxyresveratrol exhibits 63.3% inhibition at 100 µM and an IC₅₀ value of 52.7 µM on the murine tyrosinase activity. Oxyresveratrol exhibits a dose-dependent inhibitory effect on L-tyrosine oxidation by the murine tyrosinase but does not inhibit the promoter activity of the enzyme gene. Oxyresveratrol exhibits significant inhibitory effects at 10 µM and higher concentrations on murine tyrosinase activity.

In Vivo: Oxyresveratrol (2-30 mg/kg; intraperitoneal injection; twice) treatment reduces the brain infarct volume in MCAO rats. Oxyresveratrol treatment diminishes cytochrome c release and decreased caspase-3 activation, and reduces the number of apoptotic nuclei in ischemic brain in MCAO rats.

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