MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Procyanidin B2

CAS No. : 29106-49-8

MCE 国际站：Procyanidin B2

产品活性：Procyanidin B2 是一种天然黄酮类物质，具有抗肿瘤，抗氧化等作用。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶点：Reactive Oxygen Species

结构分类：黄酮类  |  双黄酮  |  酚类  |  多酚类  |  结构分类

来源：植物  |  其他科

In Vitro: Procyanidin B2 shows antiproliferative activity to MCF-7 cells, with an IC₅₀ of 19.21 μM. However, Procyanidin B2 exhibits no effect on DNA-ladder formation. Procyanidin B2 (0.1, 1, 2 μM) inhibits the activation of pyrin domain containing 3 (NLRP3) inflammasome in human umbilical vein ECs (HUVECs), and the inhibition is via suppression of AP-1 activity, and such effect can be abolished by overexpression of c-Jun. Procyanidin B2 (2 μM for 12 h) also reduces ROS in HUVECs.

In Vivo: Procyanidin B2 (40, 20, and 10 mg/kg, p.o.) protects against cerebral ischemia-induced infarct volume and brain edema in rats. Procyanidin B2 (40 mg/kg, p.o) also improves functional outcomes, regulates blood-brain barrier (BBB) permeability after cerebral ischemia. Moreover, Procyanidin B2 attenuates cerebral ischemia-induced tight junction degradation, mitochondrial depolarization and intracellular oxidative stress. Procyanidin B2 (40 mg/kg, p.o) increases Nrf2 activation and HO-1, GSTα, and NQO1 protein expression in normal brains in vivo.

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Metabolism/Protease Compound Library  |  NF-κB Signaling Compound Library  |  Stem Cell Signaling Compound Library  |  Natural Product Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Antioxidant Compound Library  |  Lipid Compound Library  |  Oxygen Sensing Compound Library  |  Ferroptosis Compound Library  |  Medicine Food Homology Compound Library  |  Phenols Library  |  Pyroptosis Compound Library  |  Traditional Chinese Medicine Active Compound Library  |  Flavonoids Library  |  Mitochondria-Targeted Compound Library  |  Food-Sourced Compound Library   |  Anti-Cancer Natural Product Library  |  Anti-inflammatory Traditional Chinese Medicine Active Compound Library  |  Plant-Sourced Natural Product Library  |  Human Metabolite Library  |  D-α-Hydroxyglutaric acid disodium  |  8α-Tigloyloxyhirsutinolide 13-O-acetate  |  Anticancer agent 120  |  7-Hydroxy-4-methyl-2(1H)-quinolone  |  N-tert-Butyl-α-phenylnitrone-d₁₄  |  BDP 581/591 NHS ester  |  Cysteamine-d₄ hydrochloride  |  L-Ascorbic acid sodium salt  |  Manganese(salen) chloride  |  Hydroxyphenyl Fluorescein  |  Glucosamine sulfate  |  Maresin 1  |  Berberine  |  1,3-Dicaffeoylquinic acid  |  Ciprofloxacin  |  Echinocystic acid  |  Lacto-N-fucopentaose I  |  Nisoldipine-d₆  |  Arg-Tyr  |  HKPerox-2  |  3-Indolepropionic acid  |  2-Methoxyestradiol-¹³C,d₃  |  Albendazole  |  QD394  |  AKBA  |  Cedrin  |  Deferoxamine  |  Ellagic acid  |  Acetylcysteine-d₃  |  N-Acetyl-D-cysteine

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

货号: HY-N0796

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。