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Glucocorticoid receptor modulator 1

CAS No. : 2868357-11-1

MCE 国际站：Glucocorticoid receptor modulator 1

产品活性：Glucocorticoid receptor modulator 1 是一种高效且具有口服活性的 NF-κB 和 AP-1 抑制剂，IC₅₀ 分别为 9 nM 和 130 nM。Glucocorticoid receptor modulator 1 可有效降低炎症因子 IL-6、IL-1β、TNF-α 的表达，可缓解小鼠皮炎。

研究领域：Vitamin D Related/Nuclear Receptor  |  NF-κB  |  Immunology/Inflammation

作用靶点：Glucocorticoid Receptor  |  NF-κB  |  AP-1

In Vitro: Glucocorticoid receptor modulator 1 (compound B53) shows inhibitory activities against NF-κB and AP-1 with IC₅₀s of 9 nM and 130 nM, respectively.
Glucocorticoid receptor modulator 1 (10 μM; 24 h) decreases the mRNA expression of the inflammatory factors of IL-6, IL-1β, TSLP, MMP-13, TNF-α, and CCL-2.

In Vivo: Glucocorticoid receptor modulator 1 (5, 10 and 20 mg/kg; p.o.; for 24 days) relieves dermatitis in mice and suppresses the expression of inflammatory factors.

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