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TRAIL/TNFSF10 Protein, Mouse (His,Solution)

MCE 国际站：TRAIL/TNFSF10 Protein, Mouse (His,Solution)

TRAIL 蛋白 (TNFSF10)，TNF 超家族的成员，是一种 II 型跨膜蛋白。TRAIL 蛋白主要与 TRAIL-R1 和 TRAIL-R2 两种受体相互作用，并诱导肿瘤或感染细胞凋亡。TRAIL 蛋白还可与 DR4、DR5 和 OPG 三种受体结合。当与 DR4 或 DR5 结合时，TRAIL 蛋白可以募集 FADD 并进一步募集和激活 caspase-8。此外，TRAIL 还可能通过激活促炎通路触发非凋亡信号通路。TRAIL 蛋白主要表达于免疫细胞表面，如细胞毒性 T 细胞和自然杀伤 (NK) 细胞。TRAIL/TNFSF10 Protein, Mouse (His) 是一种重组小鼠 TRAIL (P118-N291)，其 N 端带有 His 标签，在 E.coli 中表达。

Synonyms: rMuTRAIL/TNFSF10; TNF-related apoptosis-inducing ligand; Tumor necrosis factor ligand superfamily member 10

Species: Mouse

Source: E. coli

研究背景：TRAIL Protein (TNFSF10), a member of the TNF superfamily, is a type II transmembrane protein. TRAIL Protein is expressed in various tissues, especially in the spleen, lung, and prostate. TRAIL protein is mainly expressed on surface of immune cells, such as cytotoxic T cells and natural killer (NK) cell. TRAIL proteins on NK and T cells is critical for controlling virus infections and tumor immune surveillance.
Mouse TRAIL consists of cytoplasmic domain (M1-R17), helical domain (M18-T38), and extracellular domain (Y39-N291).Mouse TRAIL Protein shares < 70% common aa identity with human. Mouse TRAIL Protein shares 86.94% common aa identity with rat.
TRAIL Protein mainly interacts with two agonistic TRAIL receptors (TRAIL-R1 and TRAIL-R2) and induces apoptosis in tumor or infected cells. TRAIL Protein also binds with DR4, DR5, and OPG. When binding to DR4 or DR5, TRAIL Protein can recruit FADD and further recruit and activates caspase-8. Besides, TRAIL may also trigger nonapoptotic signaling through activating pro-inflammatory pathways, such as NF-κB, PI3K/Akt, and MAPK pathway.
TRAIL induces apoptosis of tumor cells in a p53 independent manner. TRAIL-based therapies has high anti-tumor potential.

蛋白编号：P50592 (P118-N291)

基因 ID：22035

产品分类：细胞因子和生长因子  |  肿瘤坏死因子超家族  |  肿瘤坏死因子配体  |  TRAIL 蛋白  |  CD 抗原  |  NK 细胞 CD 蛋白  |  CD253/TRAIL

Categories：Cytokines and Growth Factors  |  TNF Superfamily  |  TNF Superfamily Ligands  |  TRAIL Proteins  |  CD Antigens  |  NK Cell CD Proteins  |  CD253/TRAIL

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