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I-309/CCL1 Protein, Human

MCE 国际站：I-309/CCL1 Protein, Human

I-309/CCL1 Protein, Human 是一种细胞趋化因子，通过与细胞表面的 CCR8 趋化因子受体相互作用，吸引单核细胞、自然杀伤细胞、未成熟的 B 细胞核树突状细胞，介导炎症免疫反应、病毒感染以及肿瘤发生等。I-309/CCL1 Protein, Human 是一种由 E. coli表达的重组人CCL1(S23-K96)。

Synonyms: rHuI-309/CCL1; C-C motif chemokine 1; SCYA1

Species: Human

Source: E. coli

Biological Activity: 1. Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration range of 10.0-100.0 ng/mL.
2. Determined by its ability to chemoattract human monocytes population (THP-1). The ED₅₀ this effect is 64.65 ng/mL, corresponding to a specific activity is 1.547×10⁴ U/mg.

研究背景：CCL1 is a small glycoprotein belonging to the CC chemokine family with a molecular weight of approximately 15-16 kDa, known as small inducible cytokine I-309 in humans and TCA-3 in mice. CCL1 is secreted by activated monocytes, macrophages, T lymphocytes and endothelial cells and is chemotactic for monocytes but not for neutrophils.    CCL1 can be activated by interaction with the cell surface chemokine receptor CCR8, which induces Ca²⁺ influx, stimulates transient increases in cytoplasmic free calcium concentration in monocytes, and inhibits apoptosis in thymocyte lines via the RAS/MAPK pathway. Among others, CCR8 is constitutively expressed in monocytes, macrophages, Th2 and regulatory T lymphocytes and is the sole receptor for the human CCL1 and for the viral chemokine, vCCL1 (viral macrophage inflammatory protein 1). CCR8 has been shown to be associated with phagocytic macrophages and activated microglia in MS lesions and is directly related to demyelinating activity.     CCL1 is involved in inflammatory processes through leukocyte recruitment and can play a key role in angiogenesis and other viral and neoplastic processes. A number of single nucleotide polymorphisms (SNPs) in the CCL1 gene have been associated with the progression of chronic obstructive pulmonary disease (COPD). In parallel, CCL1 plays a role in various CNS functions and diseases and may be associated with neuroinflammatory disorders.

蛋白编号：P22362 (S23-K96)

基因 ID：6346

产品分类：细胞因子和生长因子  |  趋化因子  |  CC 趋化因子  |  趋化因子 CCL1

Categories：Cytokines and Growth Factors  |  Chemokine & Receptors  |  CC Chemokines  |  CCL1

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