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CD127/IL-7RA Protein, Human (216a.a, HEK293, Fc-His)

MCE 国际站：CD127/IL-7RA Protein, Human (216a.a, HEK293, Fc-His)

IL-7RA (也称CD127) 是一种 1 型膜糖蛋白，折叠后可结合并介导 IL7 和其他 α 螺旋细胞因子的作用。IL-7RA 主要由淋巴细胞表达。IL-7RA 还充当胸腺基质淋巴细胞生成素 (TSLP) 的受体。CD127/IL-7RA Protein, Human (216a.a, HEK293, Fc-His) 由 HEK293 细胞表达产生，由 216 个氨基酸(E21-G236) 组成，其 C 末端带有 His 和 Fc 标签。

Synonyms: rHuCD127, C-Fc, His; Interleukin-7 receptor subunit alpha; IL7R; IL-7R-alpha; CD127

Species: Human

Source: HEK293

研究背景：IL-7R α-chain (IL-7RA; also known as CD127) is a type 1 membrane glycoprotein folded to bind and mediate the action of IL-7 and other alpha helical cytokines. IL-7RA is almost exclusively expressed by cells of the lymphoid lineage that plays an important role in lymphocyte differentiation, proliferation, and survival.  IL-7RA gene is localised on chromosome 5p13.3.
The amino acid sequence of human IL-7RA protein has low homology between mouse and rat IL-7RA protein. While, human IL-7RA shares 97% aa sequence identity with monkey IL-7RA protein.
IL-7 is classified as a type 1 short-chain cytokine of the hematopoietin family. Physiologic roles of IL-7 involve modulation of T- and B-cell development and T-cell homeostasis. To perform all pleiotropic functions of IL-7 in immune system, IL-7 binds through a transmembrane receptor, which is formed by heterodimerizing of the common cytokine gamma chain (γc; also known as CD132) and IL-7RA. IL-7RA consists of an extracellular domain, transmembrane region and cytoplasmic tail, that recruits kinases for signal transduction. IL-7RA is organized in eight exons, spanning 18 kb of genomic DNA. The protein has a folding typical for the insertion of a helical cytokine, and it is composed of an intracellular domain (195 aa), a transmembrane domain (25 aa), and an extracellular region (220 aa). The latter shares homology with other members of the type I family of cytokine receptors. Close to the transmembrane domain, the extracellular region of IL-7Ra contains a Trp-Ser-X-Trp-Ser (WSXWS) motif involved in proper folding of the protein. Finally, the extracellular region also contains two fibronectin type III-like domains. Soluble or membrane-bound isoforms of IL-7RA are produced according to the alternative splicing of exon 6 in IL7RA gene. IL-7RA also acts as a receptor for thymic stromal lymphopoietin (TSLP).
IL-7RA associates with γc to form the functional high affinity IL-7 receptor complex. The natural killer T cells require signals from IL-7RA for their development. The common characteristic of all types of severe combined immunodeficiency (SCID) is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. Defects in IL-7RA may be associated with SCID. Meanwhile, single nucleotide polymorphisms in IL7RA gene are involved in the dysregulation of immune homeostasis and susceptibility to multiple sclerosis (MS). IL-7RA is a receptor for TSLP. TSLP indirectly regulates T cell development by modulating dendritic cell activation.

蛋白编号：P16871 (E21-G236)

基因 ID：3575

产品分类：细胞因子和生长因子  |  白细胞介素  |  白细胞介素-7 受体  |  白介素-7 受体 α  |  CD 抗原  |  B 细胞 CD 蛋白  |  白介素-7 受体 α  |  CD 抗原  |  NK 细胞 CD 蛋白  |  白介素-7 受体 α  |  CD 抗原  |  干细胞 CD 蛋白  |  白介素-7 受体 α

Categories：Cytokines and Growth Factors  |  Interleukin & Receptors  |  IL-7 Receptor  |  CD127/IL-7RA  |  CD Antigens  |  B Cell CD Proteins  |  CD127/IL-7RA  |  CD Antigens  |  NK Cell CD Proteins  |  CD127/IL-7RA  |  CD Antigens  |  Stem Cell CD Proteins  |  CD127/IL-7RA

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