MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

IL-2R beta/CD122 Protein, Canine (217a.a, HEK293, His)

MCE 国际站：IL-2R beta/CD122 Protein, Canine (217a.a, HEK293, His)

IL-2R beta (CD122)，一种表达于 T 淋巴细胞上的 Ⅰ 型细胞因子受体，是 IL-2 的受体。IL-2R beta 可介导 T 细胞免疫反应，如刺激 T 细胞增殖、激活淋巴因子激活的杀伤细胞。IL-2R beta/CD122 Protein, Canine (217a.a, HEK293, His) 是一种由 HEK293 细胞产生的、重组犬 IL-2R beta (217a.a, N30-P246), 其 C 末端带有 His 标签。

Synonyms: IL2RB; RP5-1170K4.6; CD122; P70-75

Species: Canine

Source: HEK293

Biological Activity: Measured by its ability to inhibit the IL-15-dependent proliferation of MO7e human megakaryocytic leukemic cells. The ED₅₀ for this effect is 0.4095 μg/mL in the presence of 4 ng/mL of recombinant human IL-15, corresponding to a specific activity is 2.44×10³ units/mg.

研究背景：IL-2R beta (CD122) is a type I cytokine receptor, and belongs to Type 4 subfamily. IL-2R beta is also a key component of the IL-15 receptor. IL-2R beta is broadly expressed in spleen, blood, and lymph node, such as B and T lymphocytes.
The sequence of amino acids in IL-2R beta differs in different species.
IL-2R beta cytoplasmic domain heterodimerizes with IL-2 and leads to the activation of signaling pathways: phosphoinositol 3-kinase (PI3-K)/AKT, Ras-MAP kinase, and the JAK-STAT pathways. IL-2R beta binds IL-2 with intermediate affinity. IL-2R beta mediates IL-2 internalization and signal transduction, such as cell proliferation or differentiation. IL-2R beta interacts with IL-2 and increases the proportion of CD4+ T lymphocytes. IL-2R stimulates T cell proliferation and activating lymphokine-activated killer cells.
IL-2R beta mediates T cell immune responses, and also mediates endocytosis, as well as transducing the mitogenic signals of IL-2.

蛋白编号：NP_001273780.1 (N30-P246)

基因 ID：403439

产品分类：细胞因子和生长因子  |  白细胞介素  |  白介素-2 受体  |  白介素-2 受体 beta  |  CD 抗原  |  NK 细胞 CD 蛋白  |  CD122/IL-2R beta

Categories：Cytokines and Growth Factors  |  Interleukin & Receptors  |  IL-2 Receptor  |  IL-2R beta  |  CD Antigens  |  NK Cell CD Proteins  |  CD122/IL-2R beta

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。