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GDNF Protein, Human (His)

MCE 国际站：GDNF Protein, Human (His)

Glial-cell-line-derived neurotrophic factor (GDNF) 是一种属于 GDNF 家族配体 (GFL) 的神经营养因子，可促进多巴胺神经元的存活。GDNF 对哺乳动物神经元表现出多种神经保护作用。GDNF Protein, Human (His) 是在大肠杆菌中表达产生的，由 134 个氨基酸 (S78-I211) 组成，在 N 末端带有六个 His 标签。

Synonyms: rHuGDNF; ATF

Species: Human

Source: E. coli

Biological Activity: Measured in a cell proliferation assay using SH-SY5Y human neuroblastoma cells in the presence of Recombinant Human GFR alpha 1.The ED₅₀ for this effect is 6.175 ng/mL, corresponding to a specific activity is 1.6194×10⁵ units/mg.

研究背景：Glial cell line-derived neurotrophic factor (GDNF) is a 134 amino acid protein belonging in the GDNF family ligands (GFLs). GDNF protein is widely distributed throughout both the central and peripheral nervous systems. Synthesis and secretion of GDNF occur in many cell types such as glial cells like astrocytes, oligodendrocytes, and Schwann cells; motor neurons (MNs); and skeletal muscle.
Mature human GDNF shares 91-92% amino acid sequence identity with mouse, rat, and Canine GDNF proteins. While, mouse GDNF shares 99% aa sequence identity with rat GDNF protein.
GDNF is originally isolated from cultured B49 rat glial cells and found to enhance the survival and differentiation of dopaminergic neurons in primary cultures by promoting dopamine uptake. Similar to other members of the TGF-β superfamily, GDNF is first synthesized as a precursor protein (pro-GDNF). After a series of protein cleavage and processing, the 211 amino acid pro-GDNF is finally converted into the active and mature form of GDNF. GDNF has the ability to trigger receptor tyrosine kinase RET phosphorylation, whose downstream effects have been found to promote neuronal health and survival. The binding of GDNF to its receptors triggers several intracellular signaling pathways which play roles in promoting the development, survival, and maintenance of neuron-neuron and neuron-target tissue interactions. The synthesis and regulation of GDNF have been shown to be altered in many diseases, aging, exercise, and addiction. The neuroprotective effects of GDNF may be used to develop treatments and therapies to ameliorate neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS).
GDNF is a potent neurotrophic factor for regulating MN survival in the peripheral nervous system. GDNF prevents apoptosis of MNs during development in vivo, decreases the loss of MNs in animal models of motor neuropathy and degeneration, rescues MNs from axotomy-induced cell death, and protects MNs from chronic degeneration. Intracerebral GDNF administration exerts both protective and reparative effects on the nigrostriatal dopamine system, which may have implications for the development of new treatment strategies for Parkinson's disease.

蛋白编号：P39905 (S78-I211)

基因 ID：2668

产品分类：细胞因子和生长因子  |  转化生长因子-β 超家族  |  胶质细胞源性神经营养因子家族  |  胶质细胞源性神经营养因子  |  细胞因子和生长因子  |  神经营养因子  |  胶质细胞源性神经营养因子家族  |  胶质细胞源性神经营养因子

Categories：Cytokines and Growth Factors  |  TGF-beta Superfamily  |  GDNF family  |  Glial Cell Line-derived Neurotrophic Factor (GDNF)  |  Cytokines and Growth Factors  |  Neurotrophic Factors  |  GDNF family  |  Glial Cell Line-derived Neurotrophic Factor (GDNF)

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