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(Rac)-Moxifloxacin

CAS No. : 354812-41-2

MCE 国际站：(Rac)-Moxifloxacin

产品活性：(Rac)-Moxifloxacin ((Rac)-BAY 12-8039 free base) 是 Moxifloxacin Hydrochloride (HY-66011) 的一种异构体。Moxifloxacin Hydrochloride (BAY 12-8039) 是一种口服有效的 8-甲氧基喹诺酮类抗菌活性分子，用于急性细菌性鼻窦炎，慢性支气管炎的急性细菌性加重和感染性肺炎的研究。

研究领域：Anti-infection

作用靶点：Antibiotic  |  Bacterial

In Vitro: The in vitro activities of Moxifloxacin Hydrochloride (BAY 12-8039) and Amoxicillin are compared by time-kill curve and inhibition of intracellular growth experiments by using a model of bone marrow-derived mouse macrophages infected by L. monocytogenes EGDe. Moxifloxacin acts much more rapidly, beginning to exert its effects in the first 3 h and achieving complete broth sterilization within 24 h of incubation. Moxifloxacin appears to have a protective effect against macrophage lysis, as many cells are still viable after 24 h of incubation.

In Vivo: Moxifloxacin (BAY 12-8039; 12 mg/kg; intravenous injection; once-three times per day; for 7 days; white male Wistar rats) treatment every 8 hours is accompanied by longer survival. Tissue cultures 30 hours after bacterial challenge shows considerably less bacterial overgrowth in the spleens and lungs of moxifloxacin-treated than in salinetreated animals and without being toxic.

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