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L-Ascorbic acid (GMP Like)

CAS No. : 50-81-7

MCE 国际站：L-Ascorbic acid (GMP Like)

产品活性：L-Ascorbic acid (GMP Like) 是类 GMP 级别的 L-Ascorbic acid (HY-B0166)。L-Ascorbic acid (L-Ascorbate, Vitamin C)，一种电子供体，是一种内源性抗氧化剂。L-Ascorbic acid 选择性抑制 Ca_v3.2 通道 (Ca_v3.2 channels)，IC₅₀ 为 6.5 μM。L-Ascorbic acid 还是一种胶原沉积促进剂和弹性生成抑制剂。L-Ascorbic acid通过产生活性氧 (ROS) 和选择性损伤癌细胞表现出抗癌作用。

研究领域：Immunology/Inflammation  |  Neuronal Signaling  |  NF-κB  |  Membrane Transporter/Ion Channel  |  Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Calcium Channel  |  Reactive Oxygen Species  |  Endogenous Metabolite  |  Apoptosis

In Vitro: The anti-cancer effects of L-Ascorbic acid are determined by sodium-dependent vitamin C transporter 2 (SVCT-2), a transporter of L-ascorbic acid. L-Ascorbic acid (0.1 μM-2 mM) exhibits anti-cancer effects according to SVCT-2 expression and L-ascorbic acid uptake. Human colorectal cancer cell lines displays differential responses to L-ascorbic acid, primarily depending on the expression level of SVCT-2.
L-Ascorbic acid (10 μg/ml, 5 days) enhances the reprogramming of mouse fibroblasts into IPSCs.
L-Ascorbic acid (50 μg/ml, 9 days) promotes fibroblasts conversion into cardiomyocytes.
L-Ascorbic acid (50 ng/ml, 4-6 days) facilitates generation of all-iPS cell mice from terminally differentiated B cells.

In Vivo: L-Ascorbic acid/Tolbutamide produces hypoglycaemic activity in a dose dependant manner in normal (60 mg/kg) and diabetic (40 mg/kg) condition. In the presence of L-ascorbic acid, Tolbuatmide (20 mg/kg) produces early onset of action and maintained for longer period compared to Tolbutamide matching control.

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