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IL-1 beta Protein, Rat

MCE 国际站：IL-1 beta Protein, Rat

IL-1 beta 是一种强效促炎细胞因子，由单核细胞、巨噬细胞和树突状细胞表达，在炎症和免疫反应中起关键作用。IL-1 beta 以无活性的 pro-IL-1β (由 pro-Il-1b 编码) 形式产生，以响应炎症刺激。IL-1 beta Protein, Rat 由 152 个氨基酸(V117-S268) 组成，在大肠杆菌中表达。

Synonyms: rRtIL-1β; Catabolin; IL1F2; IL-1 beta; IL1B

Species: Rat

Source: E. coli

Biological Activity: 1.The ED₅₀ is <10 pg/mL as measured by mouse D10S cells, corresponding to a specific activity of >1.0 × 10⁸ units/mg.
2.Measured in a cell proliferation assay using CTLL-2 mouse T lymphocyte. The ED₅₀ for this effect is 7.721 ng/mL, corresponding to a specific activity is 1.30×10⁵ U/mg.

研究背景：Interleukin-1β (IL-1β) is one of the pro-inflammatory cytokines and is produced and secreted by a variety of cell types although the vast majority of studies have focussed on its production within cells of the innate immune system, such as monocytes and macrophages.
IL-1β is produced as inactive pro-IL-1β (encoded by pro-Il-1b) in response to inflammatory stimuli, including both microbial products and endogenous danger-associated molecules. IL-1β gene expression and synthesis of pro-IL-1β occurs after activation of pattern recognition receptors (PRRs). Inflammatory stimuli also drive activation of cytosolic CARD and PYHIN domain-containing PRRs that recruit ASC and caspase-1 (Casp-1) to assemble into the multiprotein complex inflammasome. Pro-Casp-1 (encoded by pro-Casp-1), activated by the inflammasome, cleaves pro-IL-1β into the bioactive IL-1β. IL-1β acts in an autocrine/paracrine manner via the type I IL-1 receptor (IL-1R1).
IL-1β could regulate the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. IL-1β also plays a significant regulator of reproduction in females.

蛋白编号：Q63264 (V117-S268)

基因 ID：24494

产品分类：细胞因子和生长因子  |  白细胞介素  |  白细胞介素-1  |  白细胞介素-1 beta  |  细胞因子和生长因子  |  神经营养因子  |  白细胞介素-1  |  白细胞介素-1 beta

Categories：Cytokines and Growth Factors  |  Interleukin & Receptors  |  IL-1  |  IL-1 beta  |  Cytokines and Growth Factors  |  Neurotrophic Factors  |  IL-1  |  IL-1 beta

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