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BMP-7 Protein, Human (His)

MCE 国际站：BMP-7 Protein, Human (His)

骨形态发生蛋白 7 (BMP-7) 是一种多效性配体蛋白，属于 TGF-β 家族。BMP-7 参与调节癌细胞的增殖、侵袭和迁移，与多种人类肿瘤相关。BMP-7 结合 ALK2 或 ACVR2A/BMPR2 激发信号，该信号受 SMADs 的调控终止。BMP-7 参与 BMP-7-Smad1/5/9 信号通路，与上皮-间质转化 (EMT) 过程有关。BMP-7 也消除血管炎症，维持血管完整性，减弱血管钙化，并刺激原位磷酸骨化沉积。人 BMP-7 蛋白全长 431 个氨基酸 (M1-H454)，具有 4 个糖基化序列。重组人 BMP-7 蛋白 (His) 全长 139 个氨基酸 (S293-H431)，由 E. coli 细胞表达，带有 N 端 6*His 标签。

Synonyms: rHuBMP-7; OP-1

Species: Human

Source: E. coli

Biological Activity: Recombinant human BMP-7 induces alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. The ED₅₀ for this effect is 0.2189 μg/mL, corresponding to a specific activity is 4.568×10³ units/mg.

研究背景：Bone Morphogenetic Protein 7 (BMP-7) is a ligand protein with pleiotropic, belongs to TGFβ family. BMP-7 is involved in regulating the proliferation, invasion and migration of cancer cells, associated with a variety of human tumors.
BMP-7 also appears to exhibit anti-inflammatory effects on the vasculature, and may function to maintain vascular integrity.
BMP-7 attenuates vascular calcification, but also corrects hyperphosphatemia associated with uremia, and stimulates orthotopic skeletal phosphate deposition while simultaneously preventing vascular calcification by direct action on vascular smooth muscle cells.
BMP/TGFβ signaling to involve in vascular and valvular homeostasis, which is a critical process of embryonic development.
BMP-7 inhibits primary human aortic smooth muscle cells (SMCs) proliferation due to stimulation with serum, platelet-derived growth factor subunit BB (PDGF-BB) or TGFβ1, and maintains the expression of the vascular SMC phenotype.
And BMP/TGFβ signaling can be terminated by inhibitory SMADs including SMAD6 and SMAD7, which are activated and induced by BMP signaling and switch off BMP signaling via multiple mechanisms.
However, BMP-7 knockdown results the expression of p-Smad1/5/9 significantly decreased, accompanied with BMP-7-Smad1/5/9 signaling pathway inactive and epithelial-mesenchymal transition (EMT) process reverse.
In lung cancer, BMP-7 inhibits bone metastasis, and induces apoptosis and cell cycle arrest. In malignant melanoma, BMP-7 can induce mesenchymal-epithelial transformation and inhibit the metastasis of cancer cells. BMP-7 inhibit epithelial-mesenchymal transition (EMT)-related genes and cell invasion, inhibit telomerase, shorten telomeres, and induce the aging and apoptosis of breast cancer cells. BMP-7 has also been found to increase the cell proliferation and migration potential in a model of metastatic breast cancer in the bone and prostate cancer.
BMP-7 is widely found in different animals, while the sequence in mouse is highly similar to rat (100.00%), and human (97.67%).

蛋白编号：P18075 (S293-H431)

基因 ID：655

产品分类：细胞因子和生长因子  |  转化生长因子-β 超家族  |  骨形态发生蛋白  |  骨形态发生蛋白 7

Categories：Cytokines and Growth Factors  |  TGF-beta Superfamily  |  Bone Morphogenetic Proteins (BMPs)  |  BMP-7

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