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MCE 国际站:MIP-1 alpha/CCL3 Protein, Human
MIP-1 alpha/CCL3 Protein, Human 是一种重要的趋化因子,是免疫微环境的关键调节剂,主要介导炎症和癌症中免疫细胞的运输。MIP-1 alpha/CCL3 Protein, Human 是由E.coil 表达的重组人 CCL3 (A23-A92)。
Synonyms: rHuMIP-1α/CCL3; C-C motif chemokine 3; MIP1A; SCYA3
Species: Human
Source: E. coli
研究背景:CCL3 also known as macrophage inflammatory protein 1-a, is a member of the CC subfamily. It’s known that CCL3 is produced by monocytes/macrophages, lymphocytes, neutrophils as well as immune cells such as basophils, mast cells, fibroblasts, and dendritic cells. Meanwhile, CCL3 exerts various biological effects by binding to its three cell surface receptors, including CCR1, CCR3, and CCR5. MIP-1a induces a variety of pro-inflammatory activities such as leukocyte chemotaxis, and promotes the entry of T cells into the inflammatory tissue region from blood circulation. Chemotactic CD4+ cells, CD8+ cells, natural killer cells, and dendritic cells bind to the corresponding receptors and coordinate the occurrence of immune reactions in the immune response site by migrating through vascular endothelial cells. In addition, MIP-1a is considered as a key inflammatory mediator in granuloma, asthma, T1D as well as other autoimmune diseases.
蛋白编号:P10147 (A23-A92)
基因 ID:6348
产品分类:细胞因子和生长因子 | 趋化因子 | CC 趋化因子 | 趋化因子 CCL3
Categories:Cytokines and Growth Factors | Chemokine & Receptors | CC Chemokines | MIP-1 alpha/CCL3
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