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MCE 国际站:BMP-15 Protein, Human (His, Myc)
骨形态发生蛋白 15 (BMP-15;GDF9B) 又称生长分化因子 9B (GDF9B),是 TGFβ 家族的一种多效配体蛋白,仅在卵泡细胞中表达。BMP15 与 GDF9 密切相关,协同调控卵泡的遗传发育。BMP15 分别参与 p38 MAPK 和 HIF-1α/SCF 信号通路,可上调颗粒细胞抗苗勒氏激素 (AMH) 和多囊性卵巢综合征 (PCOS) 相关干细胞因子 (SCF) 的表达。人 BMP-15 蛋白全长 392 个氨基酸 (M1-R392),具有 4 个糖基化片段。重组人 BMP-15 蛋白 (His, Myc) 全长 125 个氨基酸 (Q268-R392),由 E. coli 大肠杆菌表达,在 N 端和 C 端分别带有 His 标签和 Myc 标签。
Synonyms: Growth/differentiation factor 9B
Species: Human
Source: E. coli
研究背景:Bone morphogenetic protein 15 (BMP-15; GDF9B), also known as growth and differentiation factor 9B (GDF9B), is a polymorphic ligand protein belonging to the TGFβ family and expresses exclusively in the oocyte.
BMP15 is closely related to GDF9, which is essential for early ovarian folliculogenesis.
BMP15 and GDF9 involve in the genetic control of follicular development. Their main functions include regulating cellular proliferation/differentiation, follicular survival/atresia, and oocyte maturation, to creat an environment supporting follicle selection and growth.
BMP15 involves in p38 MAPK pathway to up-regulate anti-Mullerian hormone (AMH) expression in granulosa cells, which is produced by granulosa cells (GCs) of preantral and small antral follicles and plays a role in regulating the recruitment of primordial follicles and the FSH-dependent development of follicles.
Otherwise, BMP15 binds HIF-1α/SCF signaling pathway to induce stem cell factor (SCF) expression in human GCs of polycystic ovary syndrome (PCOS) related follicles.
BMP-15 is widely found in different animals, while the sequence in human is different from rat (63.66%), and mouse (64.01).
蛋白编号:O95972 (Q268-R392)
基因 ID:9210
产品分类:细胞因子和生长因子 | 转化生长因子-β 超家族 | 骨形态发生蛋白 | 骨形态发生蛋白 15
Categories:Cytokines and Growth Factors | TGF-beta Superfamily | Bone Morphogenetic Proteins (BMPs) | BMP-15
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