MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
MCE 国际站:Animal-Free Activin B Protein, Human (His)
Activin B 是一种 TGFβ 超家族细胞因子,是激活素 βB 亚基的同源二聚体。Activin B 与 II 型跨膜丝氨酸-苏氨酸激酶受体(ACTRIIA 或 ACTRIIB) 结合,进而激活 I 型受体 (ACTRI),从而磷酸化并激活经典 SMAD 信号通路。Animal-Free Activin B Protein, Human (His) 是在大肠杆菌中表达产生的一种无动物成分的重组蛋白,由 115 个氨基酸(G293-407A) 组成,在 C 末端带有 His 标签。
Synonyms: Activin Beta B; INHBB; inhibin beta B chain
Species: Human
Source: E. coli
Biological Activity: Measure by its ability to induce hemoglobin expression in K562 cells. The ED50 for this effect is <0.7 ng/mL. The specific activity of recombinant human Activin B is > 1.5 x 106IU/mg
研究背景:Activins, members of the TGF-β superfamily, are first isolated from porcine ovarian follicular fluid and identified as activating factors for the release of follicle stimulating hormone. Activin B found in most tissues including placenta, reproductive organs, bone marrow, and brain. Activin B is a regulator of inflammation and immunity, and also involved in cancer or wound healing processes.
Activin B is highly conserved across species, with mouse, rat and human Activin B demonstrating >97% sequence homology.
Activins exist in three basic molecular forms composed of two inhibin β subunits: activin A (βAβA), activin B (βBβB), and activin AB (βAβB), and their receptors are ActRIA, ActRIB, ActRII A, and ActRIIB. Different additional roles have since been identified for these proteins, including broad and complex effects on cell growth and differentiation, regulation of embryogenesis, development of the reproductive system, wound healing, stem cell differentiation and regulation of immune response. Activins exert their biological functions through the serine/threonine protein kinase (MAPKs) signaling pathways. Activin B might also signal through the type IC activin receptors (ACVR1C (ALK7)). The type I receptor initiates a signaling cascade by activating a phosphorylation cascade through SMAD2/3 that complexes with SMAD4 and translocates to the cell nucleus to modulate gene transcription. The effects of activin are antagonized by inhibin, which acts by blocking activin binding to its receptors and by follistatin.
Activin B stimulates cell proliferation at the site of skin injury and promotes wound healing through the RhoA-Rock-JNK-cJun signaling pathway. Activin B production is increased in some cell types in response to inflammatory stimuli, most notably hepatic stellate cells, pituitary cells, and microglial cells. Activin B regulates cellular migration by inducing actin stress fiber formation. In addition, Activin B treatment can promote the adhesion, migration and invasion of type II endometrial cancer cells by up-regulating integrin β3 in a SMAD-dependent manner.
蛋白编号:P09529 (G293-407A)
基因 ID:3625
产品分类:细胞因子和生长因子 | 转化生长因子-β 超家族 | 激活素/抑制素 | 激活素 B | 无动物成分重组蛋白
Categories:Cytokines and Growth Factors | TGF-beta Superfamily | Activin/Inhibins | Activin B | Animal-free Recombinant Proteins
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。