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MCE 国际站:ANGPTL3/Angiopoietin-like 3 Protein, Mouse (HEK293, His)
ANGPTL3/Angiopoietin-like 3 Protein, Mouse (HEK293, His)是在 C 末端带有 10-His 标签的小鼠重组 ANGPTL3,由哺乳动物表达系统产生,并表达编码 Ser17-Thr455 的靶基因。
Synonyms: rMuAngiopoietin-like Protein 3, His; ANGPTL3; Angiopoietin-like Protein 3
Species: Mouse
Source: HEK293
研究背景:ANGPTL3/Angiopoietin-like 3 Protein is a 70 kDa 460-amino acid long secretory glycoprotein primarily expressed in the liver. Mature mouse ANGPTL3 contains an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain. ANGPTL3 is implicated in angiogenesis and atherogenesis. ANGPTL3 can regulate serum lipid levels by acting on lipoprotein lipase- (LPL-) and endothelial lipase- (EL-) mediated triglyceride (TG) and phospholipid hydrolysis. Serum ANGPTL3 levels could serve as a biomarker for future occurrence of major adverse cardiovascular events (MACEs) with coronary artery disease (CAD). ANGPTL3 acts as proangiogenic and could induce angiogenesis in vivo via binding of the C-terminal fibrinogen-like domain to the integrin αvβ3 receptor on vascular endothelial cells.
蛋白编号:Q9R182 (S17-T206)
基因 ID:30924
产品分类:细胞因子和生长因子 | 血管生成素家族 | 血管生成素样蛋白 3
Categories:Cytokines and Growth Factors | Angiopoietins | Angiopoietin Like 3 Proteins
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