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Complement C5/C5a Protein, Human

MCE 国际站：Complement C5/C5a Protein, Human

Complement C5/C5a Protein, Human是一种重组人补体 C5a。C5a是一种74个氨基酸的糖蛋白，由C系统激活产生。补体C5在补体激活的末端被蛋白质水解，产生促炎性C5a和膜攻击复合物核因子C5b。C5a是补体激活产生的炎症介质，积极调节免疫防御的各个环节，包括Toll样受体4 (TLR4) 信号。

Synonyms: rHuComplement C5/C5a; Complement C5; C5a anaphylatoxin; C5a

Species: Human

Source: E. coli

Biological Activity: Immobilized C5a at 2 μg/mL (100 μL/well) can bind anti-C5a. The ED50 is 41.72 ng/mL, corresponding to a specific activity is 2.39×10^4 units/mg.

研究背景：Complement component 5a (C5a) is a 74 amino acid glycoprotein and an important proinflammatory mediator that is cleaved enzymatically from its precursor, C5, on activation of the complement cascade. C5a is quickly metabolised by carboxypeptidases, forming the less-potent C5a desArg. C5a and C5a desArg interact with their receptors (C5aR and C5L2), which results in a number of effects which are essential to the immune response. C5a has a broad range of biological effects throughout the human body because the widespread expression of C5a receptors throughout the human organs enables C5a and C5a desArg to elicit a broad range of biological effects.

蛋白编号：P01031 (T678-R751)

基因 ID：727

产品分类：补体系统  |  补体成分 5  |  补体 C5a

Categories：Complement System  |  Complement Component 5  |  Complement Component 5a

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