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MCE 国际站:CCL24/Eotaxin-2 Protein, Human
CCL24/Eotaxin-2 Protein, Human 是一种 CC 趋化因子,可以与趋化因子受体 CCR3 相互作用以诱导嗜酸性粒细胞的趋化性,并介导特应性疾病、寄生虫感染和全身性疾病,以及促进细胞运输并调节炎症和纤维化活动。CCL24/Eotaxin-2 Protein, Human 是一种由 E. coli 表达的重组人 CCL24/Eotaxin-2(V27-A104) 蛋白。
Synonyms: rHuEotaxin-2/CCL24; C-C motif chemokine 24; CK-beta-6; MPIF-2; MPIF2; SCYA24
Species: Human
Source: E. coli
Biological Activity: Full biological activity determined by a chemotaxis bioassay using human peripheral blood eosinophils is in a concentration of 50-100 ng/ml.
研究背景:CCL24, also known as eosinophil chemotactic protein 2 (eotaxin-2) and myeloid progenitor inhibitory factor 2 (MPIF-2), is a small cytokine of the CC chemokine family, located on chromosome 7 in the human genome. CCL24 is highly chemotactic for resting T lymphocytes and eosinophils and has low chemotactic activity for neutrophils, but not for monocytes and activated lymphocytes. By binding to its sole receptor CCR3, of which CCR3, is present mainly on eosinophils, but also on basophils, monocytes, Th2 lymphocytes, epithelial cells and airway smooth muscle. CCL24 mainly mediates atopic diseases, parasitic infections and systemic diseases, but also promotes cellular transport and regulates inflammatory and fibrotic activities.
蛋白编号:O00175 (V27-A104)
基因 ID:6369
产品分类:细胞因子和生长因子 | 趋化因子 | CC 趋化因子 | 趋化因子 CCL24
Categories:Cytokines and Growth Factors | Chemokine & Receptors | CC Chemokines | Eotaxin-2/CCL24
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