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IFN-alpha 2/IFNA2 Protein, Mouse (HEK293, Fc)

MCE 国际站：IFN-alpha 2/IFNA2 Protein, Mouse (HEK293, Fc)

IFN-alpha 2 (IFNA2) 属于 I 型干扰素家族，是病毒感染的细胞分泌的一种蛋白质，作用于其他细胞并抑制病毒感染。IFN-alpha 2 对 CD8⁺ T 细胞具有细胞毒性，能够诱导 CD4⁺ T 细胞耗损增加。重组小鼠 IFN-alpha 2/IFNA2 蛋白 (HEK293, Fc) 全长 167 个氨基酸 (C24-E190)，由 HEK293 细胞产生，带有 N 端 hFc 标签。

Synonyms: Interferon alpha-2; IFN-alpha-2; LeIF A; IFNA2; IFNA2A

Species: Others

Source: HEK293

Biological Activity: 1.Measured in antiviral assays using L929 cells infected with vesicular stomatitisvirus (VSV) and the ED₅₀ is 1-8 ng/mL.
2. Measured by binding ability in a functional ELISA. Immobilized mouse IFNAR1-His at 2 μg/mL (100 μl/well) can bind IFN-alpha 2 Protein, Mouse (HEK293, Fc) and the EC₅₀ is 47.5 ng/mL.

研究背景：IFN-alpha 2 (IFNA2; IFN-α2), belongs to the type I interferon family, produced by the plasmacytoid dendritic cells (pDCs) exposure to HIV-1BaL in order to inhibit viral infection.
Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively.
IFN-alpha 2 subtype is the only one that is currently licensed to treat infections caused by hepatitis B virus (HBV) and HCV.
IFN-alpha 2 shows a Sortilin-dependent trafficking in cells and increases the expression level of interferon-stimulated genes (ISGs) in HIV-infected cells. It also exhibits cytotoxic activity against CD8⁺ T cells and enhances CD4⁺ T cell depletion.
Among the IFN-alpha 2 alleles, IFN-alpha 2b is being the predominant allele while IFNα-2a is less predominant and IFNα-2c only a minor allelic variant.
IFN-alpha 2 has a bored application in research of cancer, including some hematological malignancies and solid tumors. As for a wildly use of IFN in animal disease model, the sequence of amino acids in IFNA2a protein of mouse is very different from human (59.57%).

蛋白编号：P01573 (C24-E190)

基因 ID：15965

产品分类：细胞因子和生长因子  |  干扰素  |  干扰素 α  |  干扰素-α2a

Categories：Cytokines and Growth Factors  |  Interferon & Receptors  |  IFN-alpha  |  IFN-alpha 2a

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