MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
MCE 国际站:IL-1 beta Protein, Rhesus macaque
IL-1 beta 是一种强效促炎细胞因子,由单核细胞、巨噬细胞和树突状细胞表达,在炎症和免疫反应中起关键作用。IL-1 beta 以无活性的 pro-IL-1β (由 pro-Il-1b 编码) 形式产生,以响应炎症刺激。IL-1 beta Protein, Rhesus macaque 由 153 个氨基酸(A117-S269) 组成,在大肠杆菌中表达。
Synonyms: rRhIL-1β; IL1B
Species: Rhesus Macaque
Source: E. coli
Biological Activity: 1. The ED50 is <10 pg/mL as measured by murine D10.G4.1 cells, corresponding to a specific activity of >1.0 × 108 units/mg.
2. Measured in a proliferation assay using CTLL-2 mouse T lymphocytes cells. The ED50 this effect is 1.457 pg/mL, corresponding to a specific activity is 6.8634×10^8 units/mg.
研究背景:Interleukin-1β (IL-1β) is one of the pro-inflammatory cytokines and is produced and secreted by a variety of cell types although the vast majority of studies have focussed on its production within cells of the innate immune system, such as monocytes and macrophages.
IL-1β is produced as inactive pro-IL-1β (encoded by pro-Il-1b) in response to inflammatory stimuli, including both microbial products and endogenous danger-associated molecules. IL-1β gene expression and synthesis of pro-IL-1β occurs after activation of pattern recognition receptors (PRRs). Inflammatory stimuli also drive activation of cytosolic CARD and PYHIN domain-containing PRRs that recruit ASC and caspase-1 (Casp-1) to assemble into the multiprotein complex inflammasome. Pro-Casp-1 (encoded by pro-Casp-1), activated by the inflammasome, cleaves pro-IL-1β into the bioactive IL-1β. IL-1β acts in an autocrine/paracrine manner via the type I IL-1 receptor (IL-1R1).
IL-1β could regulate the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. IL-1β also plays a significant regulator of reproduction in females.
蛋白编号:P48090 (A117-S269)
基因 ID:704701
产品分类:细胞因子和生长因子 | 白细胞介素 | 白细胞介素-1 | 白细胞介素-1 beta | 细胞因子和生长因子 | 神经营养因子 | 白细胞介素-1 | 白细胞介素-1 beta
Categories:Cytokines and Growth Factors | Interleukin & Receptors | IL-1 | IL-1 beta | Cytokines and Growth Factors | Neurotrophic Factors | IL-1 | IL-1 beta
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。