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MCE 国际站:OX40/TNFRSF4 Protein, Mouse (HEK293, His)
OX40 (TNFRSF4) 是 OX40 配体的受体。OX40 常在 T 细胞上表达。OX40 Ligand 可以激活 OX40,从而扮演 T 细胞共刺激分子的角色。OX40-OX40 Ligand 之间的相互作用可促进效应 T 细胞存活并有效地诱导记忆 T 细胞生成,以及增强 Tfh 细胞对 B 细胞的辅助功能、促进DCs的分化和成熟。OX40/TNFRSF4 Protein, Mouse (HEK293, His) 是一种由 HEK293 产生的重组小鼠 OX40 (V20-P211),C 端带 6*His 标签。
Synonyms: Tumor necrosis factor receptor superfamily member 4; Tnfrsf4; OX40; CD134; Txgp1
Species: Mouse
Source: HEK293
研究背景:OX40 (TNFRSF4), a member of TNFR superfamily, is a receptor for OX40 Ligand. OX40 is preferentially expressed by T cells, but also found in natural killer T cells, natural killer cells, neutrophils, and human airway smooth muscle cells. Mouse OX40 shares 90% aa sequence identity with rat. Mouse OX40 shares <30% aa sequence identity with human.
OX40 Ligand can activate OX40 and thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs.
The interaction between OX40 Ligand with OX40 is essential for the generation of antigen-specific memory T cells, and induces host antitumor immunity. But the over-upregulation of OX40 and OX40L may induce abnormal activation of Tfh cells and excessive production of autoantibodies, which leads to autoimmune disease. For example, OX40 interacts with OX40 Ligand is critical for Th1 and Th2 responses in mice allergic inflammation.
蛋白编号:P47741 (V20-P211)
基因 ID:22163
产品分类:细胞因子和生长因子 | 肿瘤坏死因子超家族 | 肿瘤坏死因子受体 | OX40 | CD 抗原 | T 细胞 CD 蛋白 | CD134/OX40 | CD 抗原 | 巨噬细胞 CD 蛋白 | CD134/OX40 | 免疫检查点蛋白 | 刺激性免疫检查点
Categories:Cytokines and Growth Factors | TNF Superfamily | TNF Receptor Superfamily | OX40 | CD Antigens | T Cell CD Proteins | CD134/OX40 | CD Antigens | Macrophage CD Proteins | CD134/OX40 | Immune Checkpoint Proteins | Stimulatory Immune Checkpoint Molecules
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