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MCE 国际站:IFNAR1 Protein, Human (Biotinylated, HEK293, His-Avi)
IFNAR1,IFN-α/β 受体的亚基之一,是 I 型 IFN 受体。IFNAR1 可与 IFNAR2 形成异二聚体受体。IFNAR1 通过与酪氨酸激酶 2 (Tyk2) 相互作用而介导 IFN 诱导的 STAT 信号传导。在被这些 IFN 激活后,IFNAR1 和 IFNAR2 会发生构象变化以促进下游信号事件级联反应的发生,包括 Tyk2 和 JAK1、STAT1 和 STAT2 的磷酸化。IFNAR1 Protein, Human (Biotinylated, HEK293, His-Avi) 是一种由 HEK293 细胞产生的生物素化的重组人 IFNAR1 (K28-K436),C 端带有 His 和 Avi 标签。
Synonyms: AVP; IFN-alpha/beta R1; IFN-alpha-REC; IFNAR; IFNAR1; IFN-aR1; IFNBR; IFNbR1; IFN-R-1; CRF2-1; IFRC ; IFN-alpha/β R1
Species: Human
Source: HEK293
Biological Activity: 1.Immobilized Biotinylated Human IFNAR1 at 0.5 μg/mL (100 μL/Well) on the plate. Dose response curve for Anti-IFNAR1 Antibody hFc with the EC50 of <30.1 ng/mL determined by ELISA.
2.Immobilized Anti-IFNAR1 Antibody at 0.5 μg/mL(100 μl/Well) on the plate. Dose response curve for Biotinylated Human IFNAR1, His Tag with the EC50 of 2.8 ng/mL determined by ELISA.
研究背景:IFNAR1, one of the subunit of IFN-α/β receptor, is a type I IFN receptor. IFNAR1 is expressed on peripheral blood B cells and monocytes, and mediates differentiation and activation of these cells.
IFNAR1 forms the heterodimeric receptor (IFN-α/β receptor) together with IFNAR2. IFNAR1 interacts with tyrosine kinase 2 (Tyk2), and the interaction is able to stabilize IFNAR1 on the plasma membrane. Besides, IFNAR1 associates with TYK2 and initiates type I IFN-induced STAT signaling, but the activation needs IFNAR2 as a platform. IFN-α/-β can induce association of the IFNAR1 and IFNAR2, which makes JAK1 and TYK2 form a functional signaling unit. Upon activation by these IFNs, IFNAR1 and IFNAR2 undergo a conformational change to promote a cascade of downstream signaling events. The signaling events includes the phosphorylation of Tyk2 and JAK1, the signal transducers and activators of transcription STAT1 and STAT2, and the formation of the IFN-stimulated gene factor 3 (ISGF3) complex which consists of phosphorylated STAT1 and STAT2 and IRF9.
Human IFNAR1 consists of extracellular domain (K28-K436), helical domain (I437-A457), and cytoplasmic domain (K458-V557). The sequence of amino acids in IFNAR1 differs in different species. Human IFNAR1 shares <50% aa sequence identity with mouse.
IFNAR1 mediates IFN-induced STAT signaling by interacting with tyrosine kinase 2 (Tyk2).
蛋白编号:P17181 (K28-K436)
基因 ID:3454
产品分类:细胞因子和生长因子 | 干扰素 | 干扰素-α/β 受体 | Ⅰ型干扰素受体 1 | 生物素标记蛋白
Categories:Cytokines and Growth Factors | Interferon & Receptors | IFN-α/β Receptor | IFNAR1 | Biotinylated Proteins
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