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MCE 国际站:EGFR Protein, Human (621a.a, CHO, His)
EGFR Protein, Human (CHO, His)是在 CHO 细胞中产生的具有 his 标签的跨膜蛋白。EGFR Protein 在配体诱导激活后发挥酪氨酸激酶活性。
Synonyms: rHuEGFR, His; ERBB; ERBB1; HER1
Species: Human
Source: CHO
Biological Activity: 1. The ED50 is <1 μg/mL as measured by 3T3 cells.
2. Measured by its binding ability in a functional ELISA. Immobilized EGFR at 1 μg/ml can bind Anti- EGFR antibody, the ED50 of human EGFR protein is 13.1 ng/mL, corresponding to a specific activity is 7.63×10^4 units/mg.
研究背景:EGF Receptor (EGFR, ErbB1) is a transmembrane protein that exerts tyrosine kinase activity upon ligand induced activation. EGFR can be activated by binding EGF or at least six other structurally related protein ligands, including TGFα, HB-EGF, Betacellulin (BTC), Amphiregulin, Epiregulin, and Epigen. Upon activation, EGFR initiates a signaling cascade which includes dimerization and internalization, tyrosine phosphorylation, DNA synthesis of target genes, and, ultimately, cell proliferation. EGFR signaling plays a role in the growth and differentiation of normal cells, but elevated EGFR activity is correlated with the development and pathogenesis of certain cancers.
蛋白编号:P00533 (L25-S645)
基因 ID:1956
产品分类:细胞因子和生长因子 | EGF 超家族 | 表皮生长因子受体 | 表皮生长因子受体 1 | 受体蛋白 | 受体酪氨酸激酶 | 表皮生长因子受体 | 表皮生长因子受体 1 | 酶和调节子 | 蛋白酪氨酸激酶 | 表皮生长因子受体 | 表皮生长因子受体 1 | CAR-T 相关蛋白 | 表皮生长因子受体 1
Categories:Cytokines and Growth Factors | EGF Superfamily | EGFR/ErbB family | EGFR | Receptor Proteins | Receptor Tyrosine Kinases | EGFR/ErbB family | EGFR | Enzymes & Regulators | Protein Tyrosine Kinases | EGFR/ErbB family | EGFR | CAR-T related Proteins | EGFR
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