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BMP-2 Protein, Human/Mouse/Rat

MCE 国际站：BMP-2 Protein, Human/Mouse/Rat

骨形态发生蛋白2 (BMP-2) 是一种多效性配体蛋白，属于 TNFβ 家族，并参与关键胚胎发育的血管和瓣膜稳态。BMP-2 结合 I 型受体 (ALK-2/-3/-6) 和 II 型受体 (BMPR2, ACVR2A)，以调节各种钙化类型，包括动脉粥样硬化、慢性肾病、糖尿病、瓣膜钙化。BMP-2 在人钙化瓣膜的骨化区域中由 B 淋巴细胞和 T 淋巴细胞密集浸润区域的肌成纤维细胞和前成骨细胞过度表达，是动脉粥样硬化血管钙化与正常骨形成机制之间的连接点。重组人/小鼠/大鼠 BMP-2 蛋白长 104 个氨基酸 (Q283-R396)，由大肠杆菌表达。

Synonyms: rHuBMP-2; BMP2A; BMP-2A; BMP2

Species: Human;Rat;Mouse

Source: E. coli

Biological Activity: 1. Measured by its ability to induce alkaline phosphatase production by ATDC-5 Cells. The ED₅₀ for this effect is typically <0.2 µg/mL.
2. Measured by its ability to induce alkaline phosphatase production by C2C12 cells. The ED₅₀ for this effect is typically <1 µg/mL.

研究背景：Bone Morphogenetic Protein 2 (BMP-2) is a ligand protein with pleiotropic, belongs to TNFβ family. BMP-2 formats BMP/TGFβ signaling to involve in vascular and valvular homeostasis, which is a critical process of embryonic development.
BMP-2/TGFβ signaling can be terminated by inhibitory SMADs including SMAD6 and SMAD7, which are activated and induced by BMP signaling and switch off BMP signaling via multiple mechanisms.
BMP-2 is widely found in different animals, while the sequence in human is similar to Rat (91.86%), and mouse (92.13%).
BMPs exhibits critical contributions to the pathophysiology of atherosclerosis, pulmonary vascular disease, and vascular and valvular calcification.
BMP-2 binds different receptor, such as type I receptors (ALK-2/-3/-6) and type II receptors (BMPR2, ACVR2A), to regulate various calcification type including Atherosclerosis, Chronic Kidney Disease, Diabetes, Valvular Calcification.
BMP-2 promotes monocyte infiltration and inflammation of atherosclerotic legions.
It is linked to increased plaque formation via pro-inflammatory and pro-atherogenic effects, promoting oxidative stress, endothelial dysfunction and osteogenic differentiation.
BMP-2 is overexpressed in ossified regions of human calcified valves by myofibroblasts and pre-osteoblasts in areas densely infiltrated with B- and T-lymphocytes.
And it serves as the linkers between atherosclerotic vascular calcification with mechanisms of normal bone formation.
BMP-2 induces angiogenesis, endothelial cells (ECs) proliferation, and migration.
And BMP-2 also enhances the expression of the osteoblast and chondrocyte master transcriptional regulator RUNX2 to promote the mineralization of cultured human coronary vascular SMCs in a manner that was dependent on oxidative stress and endoplasmic reticulum (ER) stress.

蛋白编号：P12643 (Q283-R396)

基因 ID：650

产品分类：细胞因子和生长因子  |  转化生长因子-β 超家族  |  骨形态发生蛋白  |  骨形态发生蛋白 2

Categories：Cytokines and Growth Factors  |  TGF-beta Superfamily  |  Bone Morphogenetic Proteins (BMPs)  |  Bone Morphogenetic Protein 2

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