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MCE 国际站:IL-1RA/IL-1RN Protein, Human (HEK293)
IL-1RA/IL-1RN Protein, Human (HEK293)是IL-1家族的成员,可与IL-1受体结合。
Synonyms: rHuIL-1RA; IL-1RN; IRAP
Species: Human
Source: HEK293
Biological Activity: 1.The ED50 is <0.1 μg /mL as measured by D10S cells in the presence of 50.0 pg/mL Human IL-1a.
2.Measured by its ability to inhibit IL-1 alpha -dependent proliferation in CTLL-2 mouse cytotoxic T cells.The ED50 for this effect is 70.48 ng/mL in the presence of 50 pg/mL of rhIL-1 alpha, corresponding to aspecific activity is 1.419×104 units/mg.
研究背景:The production of Human Interleukin-1 Receptor Antagonist Protein (IL-1ra) is stimulated by many substances including adherent IgG, other cytokines, and bacterial or viral components. Endogenous IL-1Ra is produced in numerous experimental animal models of disease as well as in human autoimmune and chronic inflammatory diseases. Treatment of human diseases with recombinant human IL-1Ra shows an absence of benefit in sepsis syndrome. IL-1 receptor antagonist (IL-1ra) has provided a tool for blocking IL-1 activity in vivo, leading to a detailed understanding of the role of this cytokine in the inflammatory response.
蛋白编号:P18510 (R26-E177)
基因 ID:3557
产品分类:细胞因子和生长因子 | 白细胞介素 | 白细胞介素-1 受体拮抗剂
Categories:Cytokines and Growth Factors | Interleukin & Receptors | IL-1RA
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