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G-CSF Protein, Mouse (CHO)

MCE 国际站：G-CSF Protein, Mouse (CHO)

G-CSF Protein, Mouse (CHO)是调节嗜中性粒细胞生成的多肽生长因子。

Synonyms: rMuG-CSF; CSF-3; MGI-1G; Pluripoietin; Molgramostin; Sargramostim

Species: Mouse

Source: CHO

Biological Activity: The ED₅₀ is <0.02 ng/mL as measured by NFS-60 cells.

研究背景：Granulocyte Colony Stimulating Factor (G-CSF) is a cytokine that normally acts in the bone marrow microenvironment to stimulate blood cell formation. It selectively promotes growth and maturation of neutrophil progenitor cells. Granulocyte Colony Stimulating Factor receptors are present on precursor cells in the bone marrow. By binding to these receptors, Granulocyte Colony Stimulating Factor initiates proliferation and differentiation into mature granulocytes, and also stimulates bone marrow cell release into the circulation. In addition to growth promotion, Granulocyte Colony Stimulating Factor also effects phagocytosis, motility, bactericidal activity and surface molecule expression of neutrophils and monocytes. G-CSF production is induced by several inflammatory stimuli that become rapidly elevated during infection such as interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNFα) and lipopolysaccaride (LPS). Therefore, pathogen-mediated activation of host pattern recognition receptors via LPS, and the host cytokine response to infection, serve to induce circulating levels of G-CSF.

蛋白编号：P09920 (V31-A208)

基因 ID：12985

产品分类：细胞因子和生长因子  |  集落刺激因子  |  粒细胞集落刺激因子

Categories：Cytokines and Growth Factors  |  CSF & Receptors  |  G-CSF

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