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MCE 国际站:TGF beta 3/TGFB3 Protein, Human/Mouse/Rat (HEK293)
TGF-β3(转化生长因子-β3)是 TGF-β 超家族亚群的成员,具有多种细胞功能。TGF-β3 在胚胎发生和细胞分化中起作用。TGF-β3 在腭发生、伤口愈合过程中也起着关键作用。TGF-β3 能够直接与 II 型受体 (TβRII) 结合。TGF beta 3/TGFB3 Protein, Human/Mouse/Rat (HEK293) 在 HEK293 细胞中表达产生,由 112 个氨基酸 (A301-S412) 组成。
Synonyms: rHuTGF-β3; TGFB3; LAP
Species: Human;Rat;Mouse
Source: HEK293
Biological Activity: 1.The ED50 is <0.2 ng/mL as measured in a cell proliferation assay using mouse HT-2 cells.
2.Measured by its ability to inhibit the IL-4-dependent proliferation of TF-1 mouse T cells. The ED50 for this effect is 10-80 pg/mL.
研究背景:Three TGF-β isoforms have been found in mammals: TGF-β1, 2, and 3, which are structurally and functionally similar. TGF-β3 is important in embryonic development, scarless repair of injury in the embryo, adult wound healing and tissue homeostasis. It has an important role in regulating cell migration, angiogenesis, epithelial-mesenchymal transition, apoptosis, modulation of immune function, extracellular matrix (ECM) production and the regulation of ECM remodelling; biological processes that are often required for tumour growth and maintenance.
As with all members of the family, TGF-β3 is highly conserved across species, with mouse, rat and human TGF-β3 demonstrating >97% sequence homology.
TGF-β3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-β3. TGF-β3 is capable of binding directly to the type II receptor (TβRII). TGF-β3 expression increases in fetal wound healing and reduces fibronectin and collagen I and III deposition, and also improves the architecture of the neodermis. Fibroblasts are key cells in the wound healing process. In addition, TGF-β3 may actually play a protective role against tumourigenesis in a range of tissues including the skin, breast, oral and gastric mucosa. TGF-β3 is a more potent inhibitor of DNA synthesis in human keratinocytes compared to TGF-β1 and TGF-β2. TGF-β3 mRNA is expressed in lymphocytes such as CD4+ T cells, CD8+ T cells, γδT cells, and B cells. TGF-β3 has the potential to regulate systemic autoimmune diseases by inhibiting B cells. Moreover, during palatogenesis, TGF-β3 is supposed to transduce signals via both canonical Smad-dependent and non-canonical Smad-independent signaling. In human B cells, TGF-β3 induces phosphorylation of Smad1/5 along with Smad2 and Smad3.
TGF-β3 is involved in cell differentiation, embryogenesis and development. TGF-β3 is crucial in tissue regeneration and scarless tissue repair. TGF-β3 is also involved in palatogenesis, chondrogenesis, and pulmonary development. Furthermore, TGF-β3 plays a role in cancer and immune diseases.
蛋白编号:P10600 (A301-S412,Y340F)
基因 ID:7043
产品分类:细胞因子和生长因子 | 转化生长因子-β 超家族 | 转化生长因子β | 转化生长因子-β3 | 细胞因子和生长因子 | 神经营养因子 | 转化生长因子-β | 转化生长因子-β3
Categories:Cytokines and Growth Factors | TGF-beta Superfamily | Transforming Growth Factor-β | TGF-β3 | Cytokines and Growth Factors | Neurotrophic Factors | TGF- β | TGF-β3
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