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LIX/CXCL5 Protein, Mouse

MCE 国际站：LIX/CXCL5 Protein, Mouse

CXCL5，也称为中性粒细胞激活肽 78 (ENA-78)，是一种含有 ELR 基序的CXC 趋化因子。CXCL5 通过与其特异性受体 CXCR2 相互作用促进血管生成。CXCL5 由许多免疫细胞表达，例如巨噬细胞、嗜酸性粒细胞和包括间皮细胞和成纤维细胞在内的非免疫细胞。CXCL5/CXCR2 信号轴不仅有助于中性粒细胞的募集，而且还调节黑色素瘤中中性粒细胞的功能。LIX/CXCL5 Protein, Mouse 在大肠杆菌中表达产生，由 92 个氨基酸(A41-Q132) 组成。

Synonyms: C-X-C motif chemokine 5; Cytokine LIX; Cxcl5; Scyb5

Species: Mouse

Source: E. coli

Biological Activity: The biological activity determined by a chemotaxis bioassay using human peripheral blood neutrophils is in a concentration of 10-100 ng/ml.

研究背景：CXCL5 belongs to the CXC-type chemokine family with a specific amino acid sequence of glutamic acid-leucine-arginine which is shortly named as ELR motif. The ELR motif of CXC-type chemokine family plays an important role in angiogenesis. CXCL5 is expressed by many immune cells, such as macrophages, eosinophils, as well as non-immune cells including mesothelial cells, and fibroblasts.
Human CXCL5 shares 57% amino acid sequence identity with mouse and rat CXCL5.
CXCL5 can recruit cells, such as T/B lymphocytes and eosinophils from the immune system to the corresponding regions during immune response. Besides, it also participates in promoting the adhesion and remodeling of connective tissues. CXCL5 is highly expressed in various tumor tissues. CXCL5 can be used as a potential indicator of tumor prognosis. In tumor microenvironment (TME), CXCL5 binds to its receptors, such as CXCR2, to participate in the recruitment of immune cells and promote angiogenesis, tumor growth, and metastasis. Mesenchymal stem cells (MSCs) activated by acidic TME or TNF-α can secrete CXCL5 and other pro-inflammatory factors. Besides, cancer-associated mesothelial cells, which are generated by plasminogen activator inhibitor-1 (PAI-1), can secrete IL-8 and CXCL5 via the NF-κB signaling pathway and thereby promoting peritoneal metastasis. Adipose tissue-derived stem cells (ASCs) secrete CXCL5 which subsequently promotes tumor growth and affects the development of breast tumors.
The CXCL5/CXCR2 axis recruits neutrophils, promotes angiogenesis and remodels connective tissues. In addition, CXCL5 promotes angiogenesis via activating the AKT/NF-κB/FOXD1/VEGF-A pathway in a CXCR2-dependent manner. CXCL5 plays a role in cancer cell proliferation, migration, and invasion. CXCL5 promotes the proliferation of several types of tumor cells, such as the tumor cells in prostate cancer, cervical cancer, lung cancer, hepatoblastoma, and osteosarcoma.

蛋白编号：P50228 (A41-Q132)

基因 ID：20311

产品分类：细胞因子和生长因子  |  趋化因子  |  CXC 趋化因子  |  CXC 趋化因子配体 5

Categories：Cytokines and Growth Factors  |  Chemokine & Receptors  |  CXC Chemokines  |  ENA-78

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