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RANTES/CCL5 Protein, Human

MCE 国际站：RANTES/CCL5 Protein, Human

CCL5 Protein, Human 是 CC 趋化因子家族中的关键促炎趋化因子，可以与 CCR1、CCR3、CCR4 和 CCR5相互作用，介导炎症免疫反应、病毒感染以及肿瘤发生等。CCL5 Protein, Human 是一种由 E. coli 表达的重组人CCL5(S24-S91) 蛋白。

Synonyms: C-C Motif Chemokine 5; EoCP; Eosinophil Chemotactic Cytokine; SIS-Delta; Small-Inducible Cytokine A5; T Cell-Specific Protein P228; TCP228; T-Cell-Specific Protein RANTES; CCL5; D17S136E; SCYA5

Species: Human

Source: E. coli

Biological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 1.0-10.0 ng/mL.

研究背景：CCL5, also known as RANTES (Regulation of Activation, Expression and Secretion by Normal T Cells), belongs to the CC subfamily of chemokines. The CCL5 gene is located in the q11.2-q12 region of human chromosome 17 and encodes CCL5 a protein with a molecular weight of 8 kDa. CCL5 can be expressed by T cells, monocytes, NK cells, epithelial cells, fibroblasts, and CCL5 can bind to receptors CCR1, CCR3, CCR4 and CCR5, with the highest affinity for CCR5. CCL5 binding to CCR5 leads to phosphorylation of phosphatidylinositol 3-kinase ( PI3K ), and the phosphorylated PI3K further acidifies protein kinase B on serine 473, and the Akt/PKB complex phosphorylates and inactivates the serine/threonine protein kinase GSK-3. In parallel, CCL5 binding to CCR5 induces Bcl2 protein expression, which promotes cell apoptosis. CCL5 can also act as a potential agonist for the G protein-coupled receptor GPR75, which, together with GPR75, may play a role in neuronal survival by activating downstream signaling pathways involving PI3, Akt, and MAP kinases, and in insulin secretion by pancreatic islet cells by activating GPR75. In addition to acting as a chemotactic agent, CCL5 is also a major HIV suppressor produced by CD⁸⁺ T cells. It is involved in inflammation maintenance, transplantation, antiviral immunity, tumor development, and many human diseases and disorders such as viral hepatitis or COVID-19.

蛋白编号：P13501 (S24-S91)

基因 ID：6352

产品分类：细胞因子和生长因子  |  趋化因子  |  CC 趋化因子  |  趋化因子 CCL5

Categories：Cytokines and Growth Factors  |  Chemokine & Receptors  |  CC Chemokines  |  RANTES/CCL5

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