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MCE 国际站:TPO/Thrombopoietin Protein, Human (CHO, His)
TPO/Thrombopoietin Protein, Human (CHO)也称为巨核细胞生长和发育因子,是调节巨核细胞产生和血小板生成的细胞因子。
Synonyms: rHuThrombopoietin/TPO; TPO
Species: Human
Source: CHO
Biological Activity: The ED50 is typically 7.7-200 ng/mL as measured by MO7e human megakaryocytic leukemic cells in a cell proliferation assay.
研究背景:Recombinant thrombopoietin reduced radiation- and chemotherapy-induced thrombocytopenia, enhanced platelet recovery after bone marrow transplantation and increased the number of megakaryocyte precursor cells in stem cell harvests. Injection of thrombopoietin into animals stimulates the number, size and ploidy of bone marrow megakaryocytes and increases the platelet count up to ten-fold. Superphysiological amounts of Thrombopoietin/TPO (>100 ng/mL) are able to directly activate platelet aggregation in vitro. Thrombopoietin/TPO also has significant effects on platelet adhesion under flow. Low Thrombopoietin/TPO concentrations (001-1 ng/mL) accelerate firm platelet adhesion to von Willebrand factor and prevent de-attachment at higher flow rates.
蛋白编号:P40225 (S22-G353)
基因 ID:7066
产品分类:细胞因子和生长因子
Categories:Cytokines and Growth Factors
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