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IL-22 Protein, Mouse

MCE 国际站：IL-22 Protein, Mouse

IL-22 Protein, Mouse通过保护肠干细胞免受免疫介导的组织损伤从而在上皮再生和抑制慢性炎症反应中起重要作用。

Synonyms: rMuIL-22; Cytokine Zcyto 18; IL-TIF

Species: Mouse

Source: E. coli

Biological Activity: 1.The ED₅₀ is <0.5 ng/mL as measured by COLO 205 cells.
2.Measured by its ability to induce IL-10 secretion in COLO 205 human colorectal adenocarcinoma cells. The ED₅₀ for this effect is 292.3 pg/mL, corresponding to a specific activity is 3.42×10⁶ U/mg.

研究背景：Interleukin-22 (IL-22) is a member of the IL-10 family of cytokines, expressed predominantly by subsets of innate lymphoid cells (ILCs) and activated T cells, including T helper 1 (TH1) cells, TH17 cells and TH22 cells. IL-22 can be recognized by a heterodimeric receptor complex that consists of two transmembrane subunits: IL-22R1 and IL-10R2. The binding of IL-22 to its receptor activates the JAK/STAT and MAPK signaling pathway, resulting in gene expression or repression. Since the IL-10R2 is shared by five cytokines (IL-10, IL-22, IL-26, IL-28, and IL-29) and is widely expressed in most cells, the expression of the IL-22R1 determines whether a cell is the target of IL-22. IL-22 has a considerable therapeutic potential in graft-versus-host disease (GVHD), which is a frequent and challenging complication following allogeneic stem cell transplantation.

蛋白编号：Q9JJY9 (L34-V179)

基因 ID：50929

产品分类：细胞因子和生长因子  |  白细胞介素  |  白细胞介素-22

Categories：Cytokines and Growth Factors  |  Interleukin & Receptors  |  IL-22

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