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IL-5 Protein, Mouse

MCE 国际站：IL-5 Protein, Mouse

IL-5 Protein, Mouse是一种在 Th2 细胞，肥大细胞和嗜酸性粒细胞中表达的造血生长因子。

Synonyms: rMuIL-5; EDF; BCDFII; TRF

Species: Mouse

Source: E. coli

Biological Activity: The ED₅₀ is <2.0 ng/mL as measured by TF-1 cells, corresponding to a specific activity of >5.0 × 10⁵ units/mg.

研究背景：Interleukin-5 (IL-5), which is produced primarily by type 2 T helper lymphocytes (Th2), is an eosinophil differentiation and activation factor. Antagonism of IL-5 activity is being explored as a potential treatment of a number of disease conditions associated with eosinophils in animal models. Interleukin-5 (IL-5) which was previously named T cell replacing factor, B cell growth and differentiation factor, colony forming unit growth stimulating factor and eosinophil differentiation factor is produced predominantly by T cells. Mouse IL-5 is active as a growth factor on mouse but not human B cells. Mouse IL-5 stimulates the production and secretion of IgM and IgA by B cells in synergism with bacterial endotoxins. IL-5 has also been found to promote the generation of cytotoxic cells from human and mouse thymocytes. IL-5 is a potent growth promoter of early haemopoeitic progenitor cells. It stimulates the production of eosinophits from mouse, human and sheep in vitro and controls the production of eosinophils in vivo. Mouse IL-5 possesses eosinophil potentiating activity.

蛋白编号：P04401 (M21-G133)

基因 ID：16191

产品分类：细胞因子和生长因子  |  白细胞介素  |  白细胞介素-5

Categories：Cytokines and Growth Factors  |  Interleukin & Receptors  |  IL-5

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