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IL-12 Protein, Mouse (HEK293)

MCE 国际站：IL-12 Protein, Mouse (HEK293)

IL-12 蛋白是一种免疫抑制的异二聚体细胞因子，由 IL-12A 亚基 (IL-12p35) 和 IL-12B 亚基 (IL-12p40) 组成，并由树突状细胞自然产生。IL-12 具有激活和连接先天和获得性免疫应答的功能。重组小鼠 IL-12 蛋白在 HEK293 细胞中产生，全长 506 个氨基酸，不带有标记。

Synonyms: IL-12; Interleukin 12; Interleukin-12 subunit alpha; IL-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL-12 subunit p35; Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40;

Species: Mouse

Source: HEK293

Biological Activity: Measured in a cell proliferation assay using CTLL-2 cells. The ED₅₀ for this effect is 0.004776 ng/mL, corresponding to a specific activity is 2.09×10⁸ units/mg.

研究背景：IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses
IL-12 belongs to the family of interleukin-12, the only heterodimeric cytokines, including IL-12, IL-23, IL-27 and IL-35
IL-12 acts function by binding a receptor composed of IL12R1 and IL12R2 subunits, and results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2
IL-12 is an important factor for the differentiation of naive T cells into T-helper type 1 CD4+ lymphocytes secreting interferon-gamma
IL-12 induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity

蛋白编号：P43431 (R23-A215) & P43432 (M23-S335)

基因 ID：16159&16160

产品分类：细胞因子和生长因子  |  白细胞介素  |  白细胞介素-12

Categories：Cytokines and Growth Factors  |  Interleukin & Receptors  |  IL-12

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