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MCE 国际站:IL-19 Protein, Human
IL-19 Protein, Human是白细胞介素-10家族的成员。 IL-19 Protein的生物学功能和临床意义仍待研究。
Synonyms: rHuIL-19; Melanoma differentiation association like protein; ZMDA1
Species: Human
Source: E. coli
Biological Activity: The ED50 is <1.5 ng/mL as measured by murine BaF3 pro-B cells, corresponding to a specific activity of >6.7 × 105 units/mg.
研究背景:IL-19 shares 21% amino acid identity with IL-10. The exon/intron structure of IL-19 is similar to that of the human IL-10 gene, comprising five exons and four introns within the coding region of the IL-19 cDNA. IL-19 does not bind or signal through the canonical IL-10 receptor complex. IL-19 functions through a receptor complex composed of IL-20Ra and IL20Rb that is also utilized by IL-20 and IL-24. IL19 has been shown to enhance the production of Th2 cytokines in Tcells and to be elevated in asthma patients. Furthermore, it induces IL-6, IL-8 and IL-10 expression in monocytes. Additionally, it has been implicated in a range of diseases and disorders, including aging, Type-I diabetes, endotoxic shock, periodontal disease, vascular disease and rheumatoid arthritis.
蛋白编号:Q9UHD0 (L25-A177)
基因 ID:29949
产品分类:细胞因子和生长因子 | 白细胞介素 | 白细胞介素-19
Categories:Cytokines and Growth Factors | Interleukin & Receptors | IL-19
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