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MIP-3 alpha/CCL20 Protein, Human (CHO)

MCE 国际站：MIP-3 alpha/CCL20 Protein, Human (CHO)

MIP-3 alpha/CCL20 Protein, Human (CHO) 是一种 CC 趋化因子，可吸引淋巴细胞和轻微的中性粒细胞，通过与趋化因子受体 CCR6 结合并发挥作用。可诱导细胞内钙离子动员，介导癌症、各种自身免疫性疾病以及抗菌作用。MIP-3 alpha/CCL20 Protein, Human (CHO) 是一种由 CHO 细胞表达的重组人 CCL20 (A27-M96)。

Synonyms: rHuMIP-3α/CCL20; C-C motif chemokine 20; MIP3A; SCYA20

Species: Human

Source: CHO

Biological Activity: The ED₅₀ is <200 ng/mL as measured by CHO-K1/Gα15/hCCR6 cells (human Gα15 and human CCR6 stably expressed in CHO-K1 cells).

研究背景：CCL20, also known as macrophage inflammatory protein 3 alpha (MIP-3-alpha) and liver-activated regulatory chemokine (LARC), is a small cytokine belonging to the CC chemokine family and is located on chromosome 2 in the human genome. It is expressed at lower levels in the thymus, testis, prostate and intestine. CCL20 binds to and acts as a chemokine receptor CCR6 and synergistically inhibits the function of CD8 T cells with CCR6. CCL20 has antimicrobial activity and has been implicated in autoimmune diseases such as inflammatory bowel disease, rheumatoid arthritis, and psoriasis, as well as oncological diseases. It can induce Tregs to invade tumor tissue, recruit dendritic cells to promote immunosuppression, and induce endothelial cell proliferation and neointima formation.

蛋白编号：P78556 (A27-M96)

基因 ID：6364

产品分类：细胞因子和生长因子  |  趋化因子  |  CC 趋化因子  |  趋化因子 CCL20

Categories：Cytokines and Growth Factors  |  Chemokine & Receptors  |  CC Chemokines  |  MIP-3 alpha/CCL20

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