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MCE 国际站:CD45 Protein, Human (552a.a, HEK293, His)
CD45 Protein, Human (HEK 293, His) 是一种 1 型跨膜蛋白酪氨酸磷酸酶 (PTPase),由除红细胞和血小板外的所有造血干细胞 (HSC) 表达。
Synonyms: rHuReceptor-type tyrosine-protein phosphatase C/CD45, His; B220; CD45 antigen; CD45; CD45R; LCA; L-CA; LY5; protein tyrosine phosphatase, receptor type, C; PTPRC; receptor-type tyrosine-protein phosphatase C
Species: Human
Source: HEK293
Biological Activity: Measured by its ability to inhibit the proliferation of M-NFS-60 Mice myeloid leukemia lymphocytes. The ED50 this effect is 1.932 μg/ml, corresponding to a specific activity is 517.5983 units/mg.
研究背景:The leucocyte common antigen, protein tyrosine phosphatase receptor type C (PTPRC), also known as CD45, is a transmembrane glycoprotein, expressed on almost all haematopoietic cells except for mature erythrocytes, and is an essential regulator of T and B cell antigen receptor-mediated activation. CD45 is composed of two cytoplasmic domains, a transmembrane domain and an extracellular domain. Disruption of the equilibrium between protein tyrosine kinase and phosphatase activity (from CD45 and others) can result in immunodeficiency, autoimmunity, or malignancy. CD45 is normally present on the cell surface, therefore it works upstream of a large signalling network which differs between cell types, and thus the effects of CD45 on these cells are also different.
蛋白编号:P08575 (Q26-K577)
基因 ID:5788
产品分类:酶和调节子 | 磷酸酶 | 蛋白酪氨酸磷酸酶 | CD45 | CD 抗原 | T 细胞 CD 蛋白 | CD45 | CD 抗原 | B 细胞 CD 蛋白 | CD45 | CD 抗原 | 巨噬细胞 CD 蛋白 | CD45 | CD 抗原 | 单核细胞 CD 蛋白 | CD45 | CD 抗原 | 干细胞 CD 蛋白 | CD45 | CD 抗原 | 树突细胞 CD 蛋白 | CD45 | 受体蛋白 | 受体酪氨酸磷酸酶
Categories:Enzymes & Regulators | Phosphatase | Protein tyrosine phosphatases | CD45 | CD Antigens | T Cell CD Proteins | CD45 | CD Antigens | B Cell CD Proteins | CD45 | CD Antigens | Macrophage CD Proteins | CD45 | CD Antigens | Monocyte CD Proteins | CD45 | CD Antigens | Stem Cell CD Proteins | CD45 | CD Antigens | Dendritic Cell CD Proteins | CD45 | Receptor Proteins | Receptor Tyrosine Phosphatase
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