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MCE 国际站:OSM Protein, Human (209a.a)
OSM Protein, Human (209a.a)是由 209 个氨基酸组成的多肽链。OSM是属于IL-6家族的细胞因子,其在造血,间充质干细胞分化,肝再生,心脏重塑,痛觉,炎症和代谢中具有多种功能。
Synonyms: rHuOSM; OSM
Species: Human
Source: E. coli
Biological Activity: The ED50 is <10 ng/mL as measured by TF-1 cells, corresponding to a specific activity of >1.0 × 105 units/mg.
研究背景:Oncostatin M is a cytokine belonging to the IL-6 family that has multiple functions in hematopoiesis, mesenchymal stem cell differentiation, liver regeneration, heart remodeling, nociception, inflammation and metabolism. The full-length Oncostatin M proteins contain between 239 and 263 amino acids which fold into a long-chain four helix-bundle protein with an up-up-down-down topology representative of all other IL-6 family cytokines. Human Oncostatin-M can bind to either the type I receptor complex consisting of gp130 and the LIFR (gp130/LIFRb) or the type II receptor complex consisting of gp130 and the OSMR (gp130/OSMRb). In the murine system Oncostatin-M has been shown to bind with high affinity only to the type II gp130/OSMRb complex. Oncostatin-M binds to specific receptor complexes, then activates two major signaling pathways: Janus Kinase-Signal Transducers and Activators of Transcription (JAK-STAT) and Mitogen-Activated Protein Kinase (MAPK), to regulate downstream events.
蛋白编号:P13725 (A26-R234)
基因 ID:5008
产品分类:细胞因子和生长因子
Categories:Cytokines and Growth Factors
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