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MCE 国际站:IGFBP-4 Protein, Human (HEK293, C-His)
IGFBP-4 Protein, Human为胰岛素样生长因子结合蛋白家族一员,与胰岛素样生长因子 (IGF) 结合,介导 IGF 非依赖性生物活动。
Synonyms: rHuIGF-BP-4, His; IBP-4; IGFBP-4; BP4
Species: Human
Source: HEK293
Biological Activity: 1.The ED50 is <50 ng/mL, measured in a bioassay using FDC-P1 cells in the presence of 15.0 ng/ml human IGF-II.
2. Measured by its ability to inhibit the biological activity of IGF-II on MCF-7 human breast cancer cells.The ED50 is 0.07882-0.1768 μg/mL in the presence of 14 ng/mL rhIGF-II, corresponding to a specific activity is > 5656.1 units/mg
研究背景:The insulin-like growth factor-binding protein (IGFBP) family consists of six different protein members (IGFBP1-6) that show high inhibition for IGF-1 and IGF-2. IGFBP-4 is a smallest member and modulates the biologic functions by binding to IGFs. Moreover, IGFBP-4 mediates IGF-independent biologic activities. IGFBP-4 inhibits colorectal cancer, breast cancer and glioblastoma cells growth. IGFBP-4 acts a crucial inflammatory mediator in the occurrence of severities acute respiratory distress syndrome, which is responsible for cancer proliferation, migration and apoptosis.
蛋白编号:P22692 (D22-E258)
基因 ID:3487
产品分类:细胞因子和生长因子 | IGF 家族 | 胰岛素样生长因子结合蛋白 4
Categories:Cytokines and Growth Factors | IGF family | IGFBP-4
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