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MCE 国际站:TNFRSF1A Protein, Human (CHO)
TNFRSF1A (TNF RI) 蛋白具有与肿瘤坏死因子-α (TNF-α) 高度结合的能力。TNFRSF1A是 STAT3 的靶基因,调节 NF-κB 通路。TNFRSF1A 激活 NF-κB,介导细胞凋亡,并发挥炎症调节作用。TNFRSF1A Protein, Human (CHO) 由CHO 细胞表达,具有跨膜区 (D41-N201)。
Synonyms: rHuTNFRI; TNFRSF1A; TNFAR; CD120a
Species: Human
Source: CHO
Biological Activity: The ED50 is <50 ng/mL as measured by 929 cells.
研究背景:TNFRSF1A (TNF RI) protein is a single-pass type I membrane protein belonging to the tumor necrosis factor (TNF) family. TNFRSF1A is the major signaling receptor for TNF-α. TNFRSF1A protein is a multifunctional cytokine, which is synthesized by almost all cells.
The sequence of amino acids in TNFRSF1A from different species is very different (less than 85% similarity among human, rat and mouse).
TNFRSF1A contains a protein-protein interaction domain, called death domain (DD), can recruit other DD-containing proteins and couples the death receptors to caspase activation and apoptosis. Both soluble and membrane-bound forms of the cytokine can activate TNFRSF1A. TNFRSF1A induces cellular inflammatory damage and apoptosis by participating in mTOR, JNK, IKK, caspase 3, MAPK, and NF-κB pathways.
蛋白编号:P19438-1 (D41-N201)
基因 ID:7132
产品分类:细胞因子和生长因子 | 肿瘤坏死因子超家族 | 肿瘤坏死因子受体 | 肿瘤坏死因子受体超家族成员 1A
Categories:Cytokines and Growth Factors | TNF Superfamily | TNF Receptor Superfamily | TNF Receptor 1 (TNF-RI)
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