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MCE 国际站:IL-11 Protein, Mouse (HEK293)
IL-11 Protein, Mouse (HEK293)是一种 HEK293 细胞来源的多效细胞因子,在许多细胞类型中调节细胞周期,侵袭和迁移。
Synonyms: rMuIL-11; Adipogenesis inhibitory factor; AGIF
Species: Mouse
Source: HEK293
Biological Activity: The ED50 is <3 ng/mL as measured by T11 cells.
研究背景:Interleukin-11 (IL-11) is a pleiotropic cytokine that regulates cell cycle, invasion, and migration in numerous cell types, all roles critical to placental development. IL-11 is a member of the IL-6-type cytokines and signals via the IL11 receptor (R) α chain and signal transducer gp130 to activate the Janus kinase (JAK)/Signal transducers and activators of transcription (STAT)3 pathway in human endometrium and primary human extravillous trophoblast (EVT) . IL-11 is required for decidualization in humans and mice. IL11 levels are elevated in preeclampsia (PE) decidual tissue. L-11 has multiple effects on both hematopoietic and nonhematopoietic cells. Many of the biological effects described for IL-11 overlap those for IL-6. In vitro, IL-11 can synergize with IL-3, IL-4 and SCF to shorten the G0 period of early hematopoietic progenitors. IL-11 also enhances the IL-3-dependent megakaryocyte colony formation. IL-11 has been found to stimulate the T cell dependent development of specific immunoglobulin-secreting B cell.
蛋白编号:P47873 (G23-L199)
基因 ID:16156
产品分类:细胞因子和生长因子 | 白细胞介素 | 白细胞介素-11
Categories:Cytokines and Growth Factors | Interleukin & Receptors | IL-11
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