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IL-17A Protein, Human

MCE 国际站：IL-17A Protein, Human

IL-17A 是一种同型二聚体细胞因子，在宿主防御机制中对许多细菌和真菌病原体以及过敏和自身免疫反应起着关键作用。IL-17A 诱导抗菌肽、细胞因子、趋化因子和基质金属蛋白酶的产生。IL-17A Protein, Human 是一种重组人 IL-17A 蛋白，在 E. coli 中表达，由 137 个氨基酸组成(I19-A155)。

Synonyms: rHuIL-17; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8

Species: Human

Source: E. coli

Biological Activity: Measured by its ability to induce IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells and the ED₅₀ is 1-7 ng/mL.

研究背景：Interleukin-17A (IL-17A), also known as CTLA-8, belongs to the IL-17 cytokine family. IL-17A is expressed in memory Th17 cells and is a product of memory CD4⁺ T cells. IL-17A is also produced by a wide variety of immune cells, including CD8⁺ T cells, γδT cells, natural killer T (NKT) cells, monocytes, and neutrophils.
The human IL-17A shares 63.23% amino acid sequence identity with mouse and 61.90% identity with rat.
IL-17A plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides (defensins and S100 proteins), cytokines (IL-6, G-CSF, and GM-CSF), chemokines (CXCL1, CXCL5, IL-8, CCL2, and CCL7), and matrix metalloproteinases (MMP1, MMP3, and MMP13). IL-17A is detrimental in viral infection through promoting neutrophilic inflammation. IL-17A is a homodimeric cytokine and shares similar biological activities with IL-17F. IL-17A binds to IL-17RA with high affinity, and IL-17RA is required for the biological activity of IL-17A. In tumorigenesis, IL-17A recruits myeloid derived suppressor cells (MDSCs) to dampen anti-tumor immunity. IL-17A also enhances tumor growth in vivo through the induction of IL-6.
IL-17A can be used for the research of autoimmune diseases, infection and cancer.

蛋白编号：Q16552 (G24-A155)

基因 ID：3605

产品分类：细胞因子和生长因子  |  白细胞介素  |  白细胞介素-17  |  白细胞介素-17A

Categories：Cytokines and Growth Factors  |  Interleukin & Receptors  |  IL-17  |  IL-17A

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