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MCE 国际站:TGF beta 1/TGFB1 Protein, Human (Biotinylated, HEK293, His-Avi)
TGF beta 1/TGFB1 蛋白最初被认为是一种诱导啮齿动物成纤维细胞生长的生长因子。TGF beta 1/TGFB1 蛋白可将细胞阻滞在 G1 期。TGF beta 1/TGFB1 是内源性调节细胞凋亡的因子。重组人 TGF beta 1/TGFB1 蛋白 (生物素化的,HEK293细胞表达,Avi 标签)是由 HEK293 细胞表达的,带有 Avi 标签的,生物素化的,A279-S390 片段的蛋白。
Synonyms: CEDLAP; DPD1; TGF beta1; TGFB; TGFB1; TGFbeta; TGF-beta-1; TGF β1; TGFβ; TGF-β-1
Species: Human
Source: HEK293
Biological Activity: Immobilized Human ITGAV&ITGB6,His Tag at 1 μg/mL (100μL/Well) on the plate. Dose response curve for Biotinylated Human LAP(TGF beta 1), His Tag with the EC50 of 0.37-0.42 μg/mL determined by ELISA
研究背景:TGF beta 1/TGFB1 Protein (transforming growth factor beta 1) is a multifunctional cytokine, which is synthesized by almost all cells. TGF beta 1/TGFB1 Protein has a high ability to bind with TGFbRII.
The sequence of amino acids in TGFb1 proteins from different species is very stable, which leads to the conclusion that in the process of evolution, TGFb has been only slightly altered, and that both in humans and in animals, its function is similar.TGF beta 1/TGFB1 Protein is secreted as an inactive peptide, forming part of a ‘latent complex’ consisting of a mature TGFB1 dimer non-covalently bound to its latency-associated peptide (LAP) and, via LAP, to latent TGFB-binding proteins (LTBPs). Activated TGF beta 1/TGFB1 Protein binds to ubiquitously expressed cell-surface TGFB1 type I receptors (TGFBRI) and type II receptors (TGFBRII), which are transmembrane serine/threonine kinases.
TGF beta 1/TGFB1 Protein regulates cell proliferation, growth, differentiation and cells movement. TGFb1 has immunomodulatory effects. TGF beta 1/TGFB1 Protein has profibrogenic effects. TGF beta 1/TGFB1 Protein action can be local and systemic. TGF beta 1/TGFB1 Protein plays a driving role in development, fibrosis and cancer.
蛋白编号:P01137 (L30-R278, C33S)
基因 ID:7040
产品分类:细胞因子和生长因子 | 转化生长因子-β 超家族 | 转化生长因子β | 转化生长因子-β1 | 细胞因子和生长因子 | 神经营养因子 | 转化生长因子-β | 转化生长因子-β1 | 生物素标记蛋白
Categories:Cytokines and Growth Factors | TGF-beta Superfamily | Transforming Growth Factor-β | TGF-β1 | Cytokines and Growth Factors | Neurotrophic Factors | TGF- β | TGF-β1 | Biotinylated Proteins
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