耗材描述
Fortunellin
产品活性:Fortunellin 是一种黄酮类化合物,可以从金橘 (Fortunella margarita) 的果实中分离出来。Fortunellin 对小鼠的毒性很小,并能抑制 LPS 诱导的 H9C2 细胞炎症和 ROS 生成。Fortunellin 通过增强 AMPK/Nrf2 通路来防止果糖诱导的炎症和氧化应激。Fortunellin 可用于糖尿病心肌病研究。
产品来源: https://www.medchemexpress.cn/fortunellin.html
研究领域:Epigenetics | PI3K/Akt/mTOR | NF-κB
作用靶点:AMPK | Keap1-Nrf2
来源:植物 | 芸香科 | 金柑
结构分类:黄酮类 | 黄酮 | 结构分类
In Vitro: Fortunellin promotes AMPK phosphorylation to induce Nrf2 signaling, resulting in a significant decrease in oxidative stress via upregulating SOD, CAT and HO-1 as antioxidant factors.
相关产品:Natural Product Library Plus | Bioactive Compound Library Plus | Epigenetics Compound Library | Immunology/Inflammation Compound Library | NF-κB Signaling Compound Library | PI3K/Akt/mTOR Compound Library | Stem Cell Signaling Compound Library | Natural Product Library | Anti-Aging Compound Library | Antioxidant Compound Library | Anti-diabetic Compound Library | Glycoside Compound Library | Lipid Compound Library | Oxygen Sensing Compound Library | Anti-Cardiovascular Disease Compound Library | Ferroptosis Compound Library | Medicine Food Homology Compound Library | Glycolysis Compound Library | Cytoskeleton Compound Library | Traditional Chinese Medicine Active Compound Library | Flavonoids Library | Anti-Pancreatic Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Parkinson's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Anti-Obesity Compound Library | Transcription Factor-Targeted Library | Lipid Metabolism Compound Library | Glucose Metabolism Compound Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Anti-Pulmonary Fibrosis Compound Library | Pain-Related Compound Library | Multi-Target Compound Library | Radioprotector Library | Bioactive Compound Library Max | Doxorubicin hydrochloride | ML385 | Dorsomorphin | Metformin | AICAR | Resveratrol | Curcumin | 4-Octyl itaconate | Sulforaphane | Luteolin | TBHQ | Dimethyl fumarate | Omaveloxolone | A-769662 | Bardoxolone methyl | MK8722 | KI696 | Bempedoic acid | Brusatol | Ezetimibe | GSK-690693 | L-Methionine | Ergothioneine | BAY-3827 | Aldometanib | Oltipraz
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