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Colcemid
CAS No. : 477-30-5
MCE 国际站:Colcemid
产品活性:Colcemid (Demecolcine) 是一种有效的有丝分裂抑制剂,抑制微管蛋白 (tubulin) 聚合的 IC50 值为 2.4 μM。Colcemid (Demecolcine) 能与微管蛋白二聚体相互作用,诱导抗有丝分裂作用,并抑制微管生长。可用于抗炎和癌症疾病的研究。
研究领域:Cell Cycle/DNA Damage | Cytoskeleton | Apoptosis
作用靶点:Microtubule/Tubulin | Apoptosis
In Vitro: Colcemid (Demecolcine) (0.1-0.25 μg/ml, 1 h) reduces the the hypoploidy frequencies in metaphase II complements of mouse, rat and frog spermatocytes.
In Vivo: Colcemid (Demecolcine) (0.3 mg/kg for intraperitoneal injection) increases the incidence of metaphase II hypoploidy in demecolcine treated mice.
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