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trans-3-Indoleacrylic acid
CAS No. : 29953-71-7
MCE 国际站:trans-3-Indoleacrylic acid
产品活性:Trans-3-Indoleacrylic acid 是一种色氨酸代谢物,可以通过 AHR-ALDH1A3-FSP1-CoQ10 反应链抑制RSL3 (HY-100218A) 诱导的铁死亡 (ferroptosis),促进结直肠癌。
研究领域:Metabolic Enzyme/Protease | Apoptosis
作用靶点:Endogenous Metabolite | Ferroptosis
In Vitro: Trans-3-Indoleacrylic acid activites AHR for increased expression of ALDH1A3, which generates NADH for FSP1-mediated synthesis of coenzyme Q10.
Trans-3-Indoleacrylic acid inhibits RSL3 induced ferroptosis in cells HT1080 and 786-O, (50 μM, 24 h),decreases lipids peroxidation (50 μM, 4 h).
Trans-3-Indoleacrylic acid inhibits IKE-induced (10 μM) ferroptosis in HT29 tumor spheroids (100 μM, 48 h ) and HT29 organoids (100 μM, 72 h ) and promotes tumor growth.
In Vivo: Trans-3-Indoleacrylic acid (50 mg/kg, i.p., three times a week) promotes tumor development in HT29 tumor-bearing xenograft nu/nu mice .
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