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L-2-Hydroxyglutaric acid disodium
CAS No. : 63512-50-5
MCE 国际站:L-2-Hydroxyglutaric acid disodium
产品活性:L-2-Hydroxyglutaric acid disodium 是一种表观遗传修饰因子,可用于肾癌的相关研究。L-2-Hydroxyglutaric acid disodium 可抑制组蛋白去甲基化酶 (histone demethylases),从而促进组蛋白甲基化。L-2-Hydroxyglutaric acid 抑制线粒体肌酸激酶 (Mi-CK) 活性,Km 和 Ki 分别为 2.52 mM 和11.13 mM。
研究领域:Epigenetics | Metabolic Enzyme/Protease
作用靶点:Histone Demethylase | Mitochondrial Metabolism | Endogenous Metabolite
In Vitro: L-2-Hydroxyglutaric acid is potent at inhibiting 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs) including the Ten Eleven Translocation (TET) enzymes.
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