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Gardenin A
CAS No. : 21187-73-5
MCE 国际站:Gardenin A
产品活性:Gardenin A 是一种口服有效的、合成的 PMF 类似物,对神经突生长和神经元分化具有神经营养作用。Gardenin A 通过激活 PC12 细胞中的 MAPK/ERK、PKC 和 PKA 信号通路促进神经细胞的发生,但不激活 TrkA、CREB 信号通路。Gardenin A 也有镇静、抗焦虑、抗抑郁和抗惊厥作用。
研究领域:MAPK/ERK Pathway | Stem Cell/Wnt | Cell Cycle/DNA Damage | Cytoskeleton
作用靶点:ERK | PAK
In Vitro: Gardenin A (10-20 μM; 48 h) potently induces neurite outgrowth in PC12 cells, and (10 μM; 24 h and 48 h) increases expression of neuronal differentiation and synapse formation marker proteins, growth-associated protein-43 (GAP-43), and synaptophysin.
Gardenin A (10 μM; 30-120 min) markedly induces the phosphorylation of both cyclic AMP response element-binding protein (CREB) and CRE-mediated transcription, which was suppressed through the administration of the inhibitor 2-naphthol AS-E phosphate (KG-501) or using CREB siRNA.
Gardenin A (10 μM; 15-120 min) increases ERK phosphorylation and PKA and PKC activities.
In Vivo: Gardenin A (0.1-25 mg/kg; p.o.; single dose) has neuropharmacological, including sedative, anxiolytic, antidepressant, and anticonvulsant actions in mice.
Gardenin A (1-10 mg/kg; p.o.; single dose) does not affect locomotor coordination in mice and delayed the onset of convulsions.
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